ArticleFrontiers in cardiovascular medicine2017
Impact of a Genetic Risk Score for Coronary Artery Disease on Reducing Cardiovascular Risk: A Pilot Randomized Controlled Study.
Article in Frontiers in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Randomized Trial of Personal Genomics for Preventive Cardiology
Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery Disease in the Greek Population
Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care
Polygenic Risk Score to Optimize Primary Prevention in Intermediate Risk Population (PERSONAL)
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Are There Any Effective Behavior Change Strategies for Communicating Genetic Risk in Obesity Prevention and Body Weight Reduction Interventions?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Cardiovascular risk communication strategies in primary prevention. A systematic review with narrative synthesis.Journal of advanced nursing · 2022Pooled it
- Effects of polygenic risk score communication on short term health outcomes: systematic review and meta-analysis.BMJ medicine · 2026Article
- Meta-prediction of coronary artery disease risk.Nature medicine · 2025Article
- The impact of supplementing traditional risk information with polygenic risk score concerning type 2 diabetes and coronary heart disease on health behavior: a randomized controlled trial.Journal of community genetics · 2025Article
- Knowledge, attitudes and demand toward cardiovascular polygenic risk testing in clinical practice: cross-sectional survey of patients.European journal of human genetics : EJHG · 2025Article
- Review
- Another Use for Polygenic Risk Scores: Improving Risk Prediction for Heterozygous Familial Hypercholesterolemia.JACC. Advances · 2023Article
- Polygenic Scores in the Direct-to-Consumer Setting: Challenges and Opportunities for a New Era in Consumer Genetic Testing.Journal of personalized medicine · 2023Review
- Advances and Applications of Polygenic Scores for Coronary Artery Disease.Annual review of medicine · 2023Review
- Effectiveness and feasibility of cardiovascular disease personalized prevention on high polygenic risk score subjects: a randomized controlled pilot study.European heart journal open · 2022Article
- Development of a polygenic risk score to improve detection of peripheral artery disease.Vascular medicine (London, England) · 2022Article
- Clinical utility of polygenic risk scores for coronary artery disease.Nature reviews. Cardiology · 2022 · on this mapReview
- Impact of polygenic risk communication: an observational mobile application-based coronary artery disease study.NPJ digital medicine · 2022Article
- Polygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults.Circulation. Genomic and precision medicine · 2021Article
- Monogenic and Polygenic Models of Coronary Artery Disease.Current cardiology reports · 2021Review
- The GEnetic Syntax Score: a genetic risk assessment implementation tool grading the complexity of coronary artery disease-rationale and design of the GESS study.BMC cardiovascular disorders · 2021Observational
- Genomics of hypertension: the road to precision medicine.Nature reviews. Cardiology · 2021Review
- Association of a four-gene model with allergic diseases: Two-year follow-up of a birth cohort study.Immunity, inflammation and disease · 2021Article
- Promise and Peril of Population Genomics for the Development of Genome-First Approaches in Mendelian Cardiovascular Disease.Circulation. Genomic and precision medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
purposeWe tested whether providing a genetic risk score (GRS) for coronary artery disease (CAD) would serve as a motivator to improve adherence to risk-reducing strategies.
methodsWe randomized 94 participants with at least moderate risk of CAD to receive standard-of-care with (
resultsSixty-five participants completed the protocol including 30 participants in the GRS arm. We found no change in the primary outcome between participants receiving their GRS and standard-of-care participants (ΔLDL-C: -13 vs. -9 mg/dl). Among participants with a higher GRS, we observed modest effects on weight loss and physical activity. All other secondary outcomes were not significantly different, including anxiety and worry.
conclusionAdding GRS to standard-of-care did not change lipids, adherence, or psychological outcomes. Potential modest benefits in weight loss and physical activity for participants with high GRS need to be validated in larger trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.