ReviewAnesthesiology and pain medicine2017
The Efficacy of Systemic Lidocaine in the Management of Chronic Pain: A Literature Review.
Review in Anesthesiology and pain medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Comparison of Efficacy Outcomes of Lidocaine Spray, Topical Lidocaine Injection, and Lidocaine General Anesthesia in Nasal Bone Fractures Surgeries: A Randomized, Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
- Clarifying the postsurgical persistent pain after laparoscopic cholecystectomy and the role of intravenous lidocaine.Pain reports · 2025Article
- Short-Duration Systemic Lidocaine for the Management of Refractory Chronic Pain in Pediatrics.Children (Basel, Switzerland) · 2025Article
- Prolonged Pre-Eruptive Phase of Herpes Zoster Ophthalmicus in Immunocompetent Athlete: A Case of Delayed Diagnosis and Management Challenges.Clinical case reports · 2025Article
- Subcutaneous Lidocaine Infusion for Chronic Widespread Pain: A Chart Review and Survey Examining the Safety and Tolerability of Treatment.Journal of clinical medicine · 2025Article
- Hamular bursitis as a cause of orofacial pain. A case report.Journal of clinical and experimental dentistry · 2023Article
- Lidocaine infusions in chronic pain management: A prospective case series analysis.British journal of pain · 2022Article
- Lidocaine infusions and reduced opioid consumption-Retrospective experience in pediatric hematology and oncology patients with refractory pain.Pediatric blood & cancer · 2021Article
- Lidocaine Infusions for Pain Management in Pediatrics.Paediatric drugs · 2021Review
- Intravenous lidocaine alleviates postherpetic neuralgia in rats via regulation of neuroinflammation of microglia and astrocytes.iScience · 2021Article
- Utilization of Intravenous Lidocaine Infusion for the Treatment of Refractory Chronic Pain.Anesthesiology and pain medicine · 2020Review
- Lidocaine as an element of multimodal analgesic therapy in major spine surgical procedures in children: a prospective, randomized, double-blind study.Pharmacological reports : PR · 2020Article
- Efficacy of intravenous lidocaine in improving post-operative nausea, vomiting and early recovery after laparoscopic gynaecological surgery.Experimental and therapeutic medicine · 2019Article
- Intravenous infusion of lidocaine enhances the efficacy of conventional treatment of postherpetic neuralgia.Journal of pain research · 2019Article
- Comparison of the Effect of Intra-Rectal Administration of Lidocaine Gel and Lidocaine Plus Fentanyl on Pain Reduction in Prostate Biopsy: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2018Article
- Effect of Perioperative Intravenous Lignocaine Infusion on Haemodynamic Responses and postoperative Analgesia in Laparoscopic Cholecystectomy Surgeries.Anesthesiology and pain medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextDespite recent advances in the understanding of the chronic pain concept, its diagnosis and management remains a daily challenge for clinicians and patients. Based on the published literature, this review discusses and tries to organize the current knowledge and the up-to-date clinical experience about the efficacy and safety of the use of intravenous lidocaine in treatment and prevention of chronic pain. EVIDENCE ACQUISITION: To prepare this narrative review, we performed an in depth literature review using the PubMed searching engine. We extracted all relevant articles published in English, up to April 2016.
resultsLidocaine, administered as transdermal patch or intravenous lidocaine, is a safe and effective modality in the treatment of post-herpetic neuralgia (PHN), complex regional pain syndrome, as well and for prevention of chronic pain. It may be effective in the management of neuropathic pain syndromes, chronic pain, post-operative pain, and refractory cancer pain.
conclusionsIntravenous lidocaine and lidocaine patch are effective and safe for the treatment of several chronic or neuropathic pain syndromes. The use of lidocaine during surgery could prevent the development of some chronic post-surgical pain syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.