Evidence map›Paper›PMID 28856067›Full record

ArticleJournal of nanomedicine & nanotechnology2017

Application of Dendrimer-based Nanoparticles in Glioma Imaging.

Sunalee Gonawala, Meser M Ali

Open access · hybridAbstract read
In one paragraph

Article in Journal of nanomedicine & nanotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  3. Next-generation agents for fluorescence-guided glioblastoma surgery.Bioengineering & translational medicine · 2024
    Article
  4. Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sunalee GonawalaDepartment of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Meser M AliDepartment of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Henry Ford Hospital · USWayne State University · US

Funding

Treatment of glioma with nanocombretastatin with MRI monitoringR01CA206190 · NCI · HENRY FORD HEALTH SYSTEM · PI ALI, MESER M. · 2016 to 2019
$1.4M
NCI NIH HHS R01 CA206190
6 · The paper itself

Abstract

Dendritic polymers or dendrimers present an alternate template for the development of nanoparticulate-based drug delivery and imaging systems. The smaller size (~7-12 nm) of dendrimers have the advantage over the other particles, because its smaller size can possibly improve tumor penetration and the inclusion of tumor specific drug release mechanisms. A Paramagnetic Chemical Exchange Saturation Transfer (PARACEST) MRI contrast agent, Eu-DOTA-Gly4 or a clinical relevant Gd-DOTA was conjugated on the surface of a G5 PAMAM dendrimer. To create a dual mode MRI-optical imaging nanoparticle, Dylight680 was also incorporated on the amines surface of a G5 dendrimer. The particle was detected with

Indexed as

CEST MRIDual modalityGliomaOptical imaging;Tumor blood-brain barrier

Identifiers

PMID28856067
PMCPMC5573247
OpenAlexW2734933789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.