ArticleBiomedical optics express2017
Label-free optical detection of action potential in mammalian neurons.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Label-Free Functional Imaging of Vagus Nerve Stimulation-Evoked Potentials at the Cortical Surface.Research square · 2024Article
- Label-free functional imaging of vagus nerve stimulation-evoked potentials at the cortical surface.Npj biosensing · 2024Article
- Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics.Nature communications · 2022Article
- Ultra-parallel label-free optophysiology of neural activity.iScience · 2022Article
- Optical Electrophysiology: Toward the Goal of Label-Free Voltage Imaging.Journal of the American Chemical Society · 2021Article
- Detection of cellular micromotion by advanced signal processing.Scientific reports · 2020Article
- Picosecond-resolution phase-sensitive imaging of transparent objects in a single shot.Science advances · 2020Article
- INS-fOCT: a label-free, all-optical method for simultaneously manipulating and mapping brain function.Neurophotonics · 2020Article
- Label-free Optical Imaging of Membrane Potential.Current opinion in biomedical engineering · 2019Article
- Axonal Computations.Frontiers in cellular neuroscience · 2019Review
- Imaging Retinal Ganglion Cell Death and Dysfunction in Glaucoma.International ophthalmology clinics · 2019Review
- Wide-Field Functional Microscopy of Peripheral Nerve Injury and Regeneration.Scientific reports · 2018Article
- Full-field interferometric imaging of propagating action potentials.Light, science & applications · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We describe an optical technique for label-free detection of the action potential in cultured mammalian neurons. Induced morphological changes due to action potential propagation in neurons are optically interrogated with a phase sensitive interferometric technique. Optical recordings composed of signal pulses mirror the electrical spike train activity of individual neurons in a network. The optical pulses are transient nanoscale oscillatory changes in the optical path length of varying peak magnitude and temporal width. Exogenous application of glutamate to cortical neuronal cultures produced coincident increase in the electrical and optical activity; both were blocked by application of a Na-channel blocker, Tetrodotoxin. The observed transient change in optical path length in a single optical pulse is primarily due to physical fluctuations of the neuronal cell membrane mediated by a yet unknown electromechanical transduction phenomenon. Our analysis suggests a traveling surface wave in the neuronal cell membrane is responsible for the measured optical signal pulses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.