ArticleBiomedical optics express2017
Fluorescence depth estimation from wide-field optical imaging data for guiding brain tumor resection: a multi-inclusion phantom study.
Article in Biomedical optics express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Deep learning based depth map estimation of protoporphyrin IX in turbid media using dual wavelength excitation fluorescence.Biomedical optics express · 2023Article
- First experience with spatial frequency domain imaging and red-light excitation of protoporphyrin IX fluorescence during tumor resection.Biomedical optics express · 2020Article
- Visualization technologies for 5-ALA-based fluorescence-guided surgeries.Journal of neuro-oncology · 2019Review
- Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection.Journal of biomedical optics · 2018Article
- Bioluminescence imaging and two-photon microscopy guided laser ablation of GBM decreases tumor burden.Theranostics · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Studies have shown that fluorescent agents demarcate tumor from surrounding brain tissue and offer intraoperative guidance during resection. However, visualization of fluorescence signal from tumor below the surgical surface or through the appearance of blood in the surgical field is challenging. We have previously described red light imaging techniques for estimating fluorescent depths in turbid media. In this study, we evaluate these methods over a broader range of fluorophore concentrations, and investigate the ability to resolve multiple fluorescent emissions in the same plane or at different depths along the axis of imaging. A tungsten halogen lamp is used as a broadband white light source for reflectance imaging. Fluorescence from Alexa Fluor 647 is excited with a 635 nm diode laser. Reflectance and fluorescence spectral data are gathered between 670 and 720 nm with the use of a liquid crystal tunable filter and recorded on a sCMOS camera. Results show that two fluorescent emissions can be resolved within 2 mm if they are in the same plane or within 3 mm if they are at different depths along the axis of imaging up to 6 mm below the surface.
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Registered trials
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