Evidence map›Paper›PMID 28855892›Full record

ArticleFrontiers in endocrinology2017

Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study.

João Soares Felício, Alana Ferreira de Oliveira, Amanda Soares Peixoto, Ana Carolina Contente Braga de Souza, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Carolina Tavares Carvalho, Manuela Nascimento de Lemos, Sávio Diego Nascimento Cavalcante, Fabricio de Souza Resende and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Impact of vitamin D and vitamin D receptor activator in diabetic nephropathy.Frontiers in clinical diabetes and healthcare · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

João Soares FelícioUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Alana Ferreira de OliveiraUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Amanda Soares PeixotoUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Ana Carolina Contente Braga de SouzaUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
João Felício Abrahão NetoUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Franciane Trindade Cunha de MeloUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Carolina Tavares CarvalhoUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Manuela Nascimento de LemosUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Sávio Diego Nascimento CavalcanteUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Fabricio de Souza ResendeUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Márcia Costa Dos SantosUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Ana Regina MottaUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Luísa Corrêa JanaúUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Elizabeth Sumi YamadaUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Karem Miléo FelícioUniversity Hospital João de Barros Barreto, Federal University of Pará, Endocrinology Division, Belém, Brazil.
Universidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSome studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD.

methods22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient's previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation.

resultsThere was a reduction of DKD prevalence at the end of the study (68 vs 32%;

conclusionOur pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM.

Indexed as

cholecalciferoldiabetes kidney diseasehigh dose vitamin D supplementationnephropathytype 1 diabetes mellitusvitamin D supplementation

Identifiers

PMID28855892
PMCPMC5557778
OpenAlexW2743282786

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.