ReviewFrontiers in neurology2017
Laser Doppler Assessment of Vasomotor Axon Reflex Responsiveness to Evaluate Neurovascular Function.
Review in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Heart rate variability biofeedback in patients with functional dizziness.Journal of neurology · 2025Trial
- Thermoregulatory Dysfunction in Parkinson's Disease: Mechanisms, Implications, and Therapeutic Perspectives.Cells · 2025Review
- Screening and monitoring of diabetic polyneuropathy in clinical practice: present and future with connected devices.Frontiers in neurology · 2025Article
- Facial functional networks during resting state revealed by thermal infrared imaging.Physical and engineering sciences in medicine · 2023Article
- Contactless photoplethysmography for assessment of small fiber neuropathy.Frontiers in physiology · 2023Article
- Effects of digitalized university curriculum-associated teaching on the equilibrium of autonomic neurophysiology and disposition of learners in medical school (EDUCATE-AND-LEARN): protocol for a randomized crossover study.Annals of medicine · 2021Article
- Effect of sensory blockade and rate of sensory stimulation on local heating induced axon reflex response in facial skin.Autonomic neuroscience : basic & clinical · 2021Article
- Remote Photoplethysmography for Evaluation of Cutaneous Sensory Nerve Fiber Function.Sensors (Basel, Switzerland) · 2021Article
- Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres.Diagnostics (Basel, Switzerland) · 2021Review
- A Systematic Review of the Diagnostic Methods of Small Fiber Neuropathies in Rehabilitation.Diagnostics (Basel, Switzerland) · 2020Review
- Assessment of cutaneous axon-reflex responses to evaluate functional integrity of autonomic small nerve fibers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Guideline "diagnosis and non interventional therapy of neuropathic pain" of the German Society of Neurology (deutsche Gesellschaft für Neurologie).Neurological research and practice · 2020Article
- Bridging the Gap Between Vessels and Nerves in Fabry Disease.Frontiers in neuroscience · 2020Article
- Axonotmesis-evoked plantar vasodilatation as a novel assessment of C-fiber afferent function after sciatic nerve injury in rats.Neural regeneration research · 2019Article
- Increased TRPM4 Activity in Cerebral Artery Myocytes Contributes to Cerebral Blood Flow Reduction After Subarachnoid Hemorrhage in Rats.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Article
- High-resolution axon reflex sweat testing for diagnosis of neuropathy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Article
- Architecture of the Cutaneous Autonomic Nervous System.Frontiers in neurology · 2019Review
- Axon reflex-mediated vasodilation is reduced in proportion to disease severity in TTR-FAP.Neurology. Genetics · 2018Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vasomotor axon reflex can be evoked in peripheral epidermal nociceptive C-fibers to induce local vasodilation. This neurogenic flare response is a measure of C-fiber functional integrity and therefore shows impairment in patients with small fiber neuropathy. Laser Doppler flowmetry (LDF) and laser Doppler imaging (LDI) are both techniques to analyze vasomotor small fiber function by quantifying the integrity of the vasomotor-mediated axon reflex. While LDF assesses the flare response following acetylcholine iontophoresis with temporal resolution at a single defined skin point, LDI records flare responses with spatial and temporal resolution, generating a two-dimensional map of superficial blood flow. LDF is characterized by a high intra- and interindividual measurement variability, which is smaller in LDI due to its spatial resolution. Nevertheless, LDI still lacks standardized methods for image analysis. Consequently, use of the technique currently remains on an experimental level. Here, we sought to review the current literature on laser Doppler assessment of vasomotor function and discuss potential future applications of established techniques as well as those that are still experimental.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.