ArticleBMC clinical pathology2017
Cerebrospinal fluid pleocytosis level as a diagnostic predictor? A cross-sectional study.
Article in BMC clinical pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 22 citations in OpenAlex.
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- The Evaluation of a Rapid Syndromic Multiplex Meningitis/Encephalitis RT-qPCR MX-17 Panel.Diagnostics (Basel, Switzerland) · 2025Article
- Sysmex XN-Based Evaluation of the Diagnostic Performance of High-Fluorescent Cells From CSF as a Supportive Diagnostic Criterion in Neurological Diseases.International journal of laboratory hematology · 2025Article
- Adverse Reactions to the Orphan Drug Cerliponase Alfa in the Treatment of Neurolipofuscinosis Type 2 (CLN2).Pharmaceuticals (Basel, Switzerland) · 2024Article
- Pediatric tuberculosis in Mexico: A retrospective analysis of 100 patients.Journal of clinical tuberculosis and other mycobacterial diseases · 2024Article
- Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections.The Journal of infection · 2024Article
- Seizures in adults with suspected central nervous system infection.BMC neurology · 2022Article
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- Neurobrucellosis: report of 54 cases.Tropical medicine and health · 2022Article
- Neuroimmunological investigations of cerebrospinal fluid in patients with recent onset depression - a study protocol.BMC psychiatry · 2022Article
- Comment on 'MOG antibody-associated encephalomyelitis mimicking bacterial meningomyelitis following ChAdOx1 nCoV-19 vaccination: a case report'.Therapeutic advances in neurological disorders · 2022Article
- Anti-NMDAR encephalitis presenting after immature teratoma resection.BMJ case reports · 2021Article
- COVID-19 Encephalitis with SARS-CoV-2 Detected in Cerebrospinal Fluid Presenting as a Stroke Mimic.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Article
- A Cross-Sectional Study of Hyponatremia Associated with Acute Central Nervous System Infections.Journal of clinical medicine · 2019Article
- Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis.International journal of molecular sciences · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLumbar puncture with quantification of leukocytes and differential count of cellular subsets in the cerebrospinal fluid is a standard procedure in cases of suspected neuroinfectious conditions. However, a number of non-infectious causes may result in a low leukocyte number (0-1000 cells/ml). We wanted to assess the diagnostic diversity of unselected adult patients with pleocytosis in the cerebrospinal fluid.
methodsThe study is based on data from cerebrospinal fluid (CSF) analyses of all adult patients (15 years or older) admitted to a large university hospital in Denmark during a two-year period (2008-2009). Data from the local patient administrative system supplied with data from patient charts were combined with laboratory data.
resultsA total of 5390 cerebrospinal fluid samples from 3290 patients were included. Pleocytosis >5 leucocytes/μl was found in samples from 262 patients of which 106 (40.5%) were caused by infection of the central nervous system (CNS), 20 (7.6%) by infection outside CNS, 79 (30.2%) due to non-infectious neurological diseases, 23 (8.8%) by malignancy, and 34 (13.0%) caused by other conditions. Significantly higher mean CSF leukocytes was found in patients suffering from CNS infection (mean 1135 cells/μl,
conclusionsCNS infection, non-infectious neurological disease, malignancy, and infection outside CNS can cause pleocytosis of the cerebrospinal fluid. Leukocyte counts above 100/μl is mainly caused by CNS infection, whereas the number of differential diagnoses is higher if the CSF leukocyte counts is below 50/μl. These conditions are most commonly caused by non-infectious neurological diseases including seizures.
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