Evidence map›Paper›PMID 28855741›Full record

ReviewNature reviews. Neuroscience2017

The impact of cytoskeletal organization on the local regulation of neuronal transport.

Jeffrey J Nirschl, Amy E Ghiretti, Erika L F Holzbaur

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Basic Pathological Mechanisms in Peripheral Nerve Diseases.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Axon Initial Segments Are Required for Efficient Motor Neuron Axon Regeneration and Functional Recovery of Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  15. Multiple roles for the cytoskeleton in ALS.Experimental neurology · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Mechanisms of Chemotherapy-Induced Neurotoxicity.Frontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeffrey J NirschlDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, 638A Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.
Amy E GhirettiDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, 638A Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.
Erika L F HolzbaurDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, 638A Clinical Research Building, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.
University of Pennsylvania · US

Funding

The Interaction of Cytoplasmic Dynein and DynactinR01GM048661 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI HOLZBAUR, ERIKA L · 1993 to 2017
$6.0M
Mechanistic analysis of axonal transport defects in neurodegenerative diseaseR37NS060698 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HOLZBAUR, ERIKA L · 2014 to 2020
$2.9M
Pathogenic Mechanisms of Reduced Transport Initiation in Perry SyndromeF30NS092227 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI NIRSCHL, JEFFREY JOHN · 2015 to 2017
$118k
NIGMS NIH HHS R01 GM048661NINDS NIH HHS R37 NS060698
6 · The paper itself

Abstract

Neurons are akin to modern cities in that both are dependent on robust transport mechanisms. Like the best mass transit systems, trafficking in neurons must be tailored to respond to local requirements. Neurons depend on both high-speed, long-distance transport and localized dynamics to correctly deliver cargoes and to tune synaptic responses. Here, we focus on the mechanisms that provide localized regulation of the transport machinery, including the cytoskeleton and molecular motors, to yield compartment-specific trafficking in the axon initial segment, axon terminal, dendrites and spines. The synthesis of these mechanisms provides a sophisticated and responsive transit system for the cell.

Indexed as

Biological TransportAnimalsCytoskeletonHumansModels, NeurologicalMolecular Motor ProteinsNeuronsMolecular Motor Proteins

Identifiers

PMID28855741
PMCPMC6400490
OpenAlexW2752756088

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.