Evidence map›Paper›PMID 28855662›Full record

ArticleScientific reports2017

TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants.

Junyun Lai, Joanna Ai Ling Choo, Wei Jian Tan, Chien Tei Too, Min Zin Oo, Manuel A Suter, Fatimah Bte Mustafa, Nalini Srinivasan, Conrad En Zuo Chan, Andrew Guo Xian Lim and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. TCR-like antibody and GITR signaling lead to effective CAR-T against solid tumor.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  3. Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Epstein-Barr Virus and the Human Leukocyte Antigen Complex.Current clinical microbiology reports · 2019
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Junyun LaiImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Joanna Ai Ling ChooDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.
Wei Jian TanImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Chien Tei TooImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Min Zin OoImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Manuel A SuterImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Fatimah Bte MustafaImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Nalini SrinivasanDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.
Conrad En Zuo ChanDefense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, 117510, Singapore.
Andrew Guo Xian LimImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Youjia ZhongImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
Soh Ha ChanDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.
Brendon J HansonDefense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, 117510, Singapore.
Nicholas R J GascoigneDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.ORCID 0000-0001-9980-4225
Paul A MacAryImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore. paul_macary@nuhs.edu.sg.
National University of Singapore · SGDSO National Laboratories · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is a common gammaherpesvirus associated with various human malignancies. Antibodies with T cell receptor-like specificities (TCR-like mAbs) provide a means to target intracellular tumor- or virus-associated antigens by recognising their processed peptides presented on major histocompatibility complex (MHC) class I (pMHC) complexes. These antibodies are however thought to be relevant only for a single HLA allele. Here, we show that HLA-A*02:01-restricted EBV antigenic peptides EBNA1

Indexed as

Antibodies, MonoclonalAntibody-Dependent Cell CytotoxicityCell Line, TumorGenetic VariationHerpesviridae InfectionsHerpesvirus 4, HumanHLA-A2 AntigenHumansModels, MolecularPeptide FragmentsReceptors, Antigen, T-CellAntibodies, MonoclonalHLA-A*02 antigenHLA-A2 AntigenPeptide FragmentsReceptors, Antigen, T-Cell

Identifiers

PMID28855662
PMCPMC5577143
OpenAlexW2746475302

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.