ArticleScientific reports2017
Peripheral serotonin regulates postoperative intra-abdominal adhesion formation in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Development of urinary impairment after spinal cord injury courses with altered urethral serotonin signalling in the female mice.Scientific reports · 2025Article
- Potential of tadalafil and tadalafil-cellulose nanocomposite in preventing postsurgical abdominal adhesions in a rat cecal abrasion model.Scientific reports · 2025Article
- Effects of linalool on postoperative peritoneal adhesions in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects.Inflammopharmacology · 2024Article
- Unravelling the role of Sildenafil and SB204741 in suppressing fibrotic potential of peritoneal fibroblasts obtained from PD patients.Frontiers in pharmacology · 2023Article
- Rosmarinic acid prevents post-operative abdominal adhesions in a rat model.Scientific reports · 2022Article
- Prevention of surgical adhesions with gelatine sealing sheet in a canine adhesion model.Interactive cardiovascular and thoracic surgery · 2022Article
- The Inhibitory Effects of Naringin in a Rat Model of Postoperative Intraperitoneal Adhesion Formation.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- AICAR attenuates postoperative abdominal adhesion formation by inhibiting oxidative stress and promoting mesothelial cell repair.PloS one · 2022Article
- Transcriptome sequencing analysis of primary fibroblasts: a new insight into postoperative abdominal adhesion.Surgery today · 2022Article
- Extracellular Vesicles Derived from Adipose Mesenchymal Stem Cells Promote Peritoneal Healing by Activating MAPK-ERK1/2 and PI3K-Akt to Alleviate Postoperative Abdominal Adhesion.Stem cells international · 2022Article
- The Therapeutic Potential of Targeting Key Signaling Pathways as a Novel Approach to Ameliorating Post-Surgical Adhesions.Current pharmaceutical design · 2022Review
- Changes of fibrinolytic system in thrombolytic resuscitation of pulmonary thromboembolism-induced cardiac arrest model.International wound journal · 2021Article
- Post-Operative Adhesions: A Comprehensive Review of Mechanisms.Biomedicines · 2021Review
- Salvia miltiorrhiza hydroalcoholic extract inhibits postoperative peritoneal adhesions in rats.BMC complementary medicine and therapies · 2021Article
- The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review.BMC surgery · 2021Review
- TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells.Oxidative medicine and cellular longevity · 2021Article
- Laparoscopic procedures impact on mast cell mediators, extracellular matrix and adhesion scoring system in rats.Annals of medicine and surgery (2012) · 2020Article
- Cx3cr1Molecular brain · 2020Article
- The Role of Serotonin in Concanavalin A-Induced Liver Injury in Mice.Oxidative medicine and cellular longevity · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study is to investigate the role and potential mechanisms of peripheral serotonin in postoperative intra-abdominal adhesion formation in mice. The caecum-rubbing operations were conducted for intra-abdominal adhesion formation modelling in wild-type and Tph1-/- mice. The deficiency of serotonin significantly decreased the adhesion scores, weight loss, and adhesion thickness as well as levels of collagen fibres and hydroxyproline in the adhesive tissues. The Tph1-/- mice exhibited a milder inflammatory response and oxidative stress in the adhesive tissues than did the wild-type mice. Moreover, the deficiency of serotonin reduced the levels of PAI-1 and fibrinogen, and raised the t-PA and t-PA/PAI levels in the peritoneal fluids. Moreover, the expressions of CD34, VEGF, TGF-β and 5-HT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.