ArticleScientific reports2017
A comprehensive analysis of the association of common variants of ABCG2 with gout.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Single-nucleotide polymorphisms link gout with health-related lifestyle factors in Korean cohorts.PloS one · 2023Pooled it
- The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.BMC medical genetics · 2020Pooled it
- Integrative Genome-Wide Association Studies of eQTL and GWAS Data for Gout Disease Susceptibility.Scientific reports · 2019Pooled it
- Inverse relationship of oxidative balance score with hyperuricemia among Chinese adults: a population-based cross-sectional study.BMC public health · 2025Observational
- A combination of red and processed meat intake and polygenic risk score influences the incidence of hyperuricemia in middle-aged Korean adults.Nutrition research and practice · 2024Article
- Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.Science (New York, N.Y.) · 2024Article
- The Evolving Landscape of Gout in the Female: A Narrative Review.Gout, urate, and crystal deposition disease · 2023Article
- The frequency of majorPharmacogenomics · 2023Article
- Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation.Frontiers in human neuroscience · 2023Article
- Genetic assessment of hyperuricemia and gout in Asian, Native Hawaiian, and Pacific Islander subgroups of pregnant women: biospecimens repository cross-sectional study.BMC rheumatology · 2022Article
- Multidrug efflux transporter ABCG2: expression and regulation.Cellular and molecular life sciences : CMLS · 2021Review
- Impact ofGenes · 2021Article
- Comprehensive Analysis ofGenes · 2020Article
- Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter.Cellular and molecular life sciences : CMLS · 2020Article
- Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism.Cells · 2019Review
- Polymorphisms ofMedicina (Kaunas, Lithuania) · 2019Article
- Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.The open rheumatology journal · 2018Review
- Predicting nifedipine responses in preterm labor: a risk score incorporating ABCG2 polymorphisms and clinical factors.PharmacogenomicsArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2 are susceptibility loci associated with gout. Haplotype analysis revealed five blocks across the ABCG2 locus were associated with an increased risk of gout with odds ratios (ORs) from 2.59-3.17 (all P < 0.0001). A novel finding in the present study was the identification of rs3114018 in block 3 and its association with increased gout risk. We found that the rs2231142T allele in block 2 and the rs3114018C-rs3109823T (C-T) risk haplotype in block 3 conferred the greatest evidence of association to gout risk (P = 1.19 × 10
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