ArticleScientific reports2017
Mitogenome Sequencing in the Genus Camelus Reveals Evidence for Purifying Selection and Long-term Divergence between Wild and Domestic Bactrian Camels.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Whole Mitochondrial Genome Analysis Highlights India's Role in Pig Domestication and Maternal Lineage Diversification.Biochemical genetics · 2026Article
- Draft Genome Assembly and Annotation of a Male Mezayen Dromedary Camel of the Majaheem Type (Animals : an open access journal from MDPI · 2026Article
- Mitochondrial Genomic Characteristics and Maternal Genetic Differentiation of Different Geographical Populations ofAnimals : an open access journal from MDPI · 2026Article
- Global cytochrome c oxidase subunit I analysis reveals mitochondrial conservation in Camelus dromedarius with clear interspecific separation from other camelids.Molecular biology reports · 2026Article
- Challenges of Introgression in Conservation: Genetic Diversity of the Endangered Wild Camel (Ecology and evolution · 2026Article
- Article
- Phylogenetic Analysis of Indian Dromedary Breeds Based on the Mitochondrial D-Loop Marker.Animals : an open access journal from MDPI · 2025Article
- The power of coalescent methods for inferring recent and ancient gene flow in endangered Bactrian camels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Mitochondrial DNA of the Arabian CamelAnimals : an open access journal from MDPI · 2024Review
- Article
- Analysis of Genetic Diversity and Population Structure of Tarim and Junggar Bactrian Camels Based on Simplified GBS Genome Sequencing.Animals : an open access journal from MDPI · 2023Article
- Article
- Active Sulfate-Reducing Bacterial Community in the Camel Gut.Microorganisms · 2023Article
- The Flourishing Camel Milk Market and Concerns about Animal Welfare and Legislation.Animals : an open access journal from MDPI · 2022Article
- The mammalian brain under domestication: Discovering patterns after a century of old and new analyses.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Review
- Review of genetic diversity in Bactrian camel (Animal frontiers : the review magazine of animal agriculture · 2022Article
- Mitochondrial DNA variation and phylogeography of Old World camels.Animal bioscience · 2021Article
- Aspects of Molecular Genetics in Dromedary Camel.Frontiers in genetics · 2021Review
- Whole-genome sequencing of 128 camels across Asia reveals origin and migration of domestic Bactrian camels.Communications biology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 8 countries.
Funding
Abstract
The genus Camelus is an interesting model to study adaptive evolution in the mitochondrial genome, as the three extant Old World camel species inhabit hot and low-altitude as well as cold and high-altitude deserts. We sequenced 24 camel mitogenomes and combined them with three previously published sequences to study the role of natural selection under different environmental pressure, and to advance our understanding of the evolutionary history of the genus Camelus. We confirmed the heterogeneity of divergence across different components of the electron transport system. Lineage-specific analysis of mitochondrial protein evolution revealed a significant effect of purifying selection in the concatenated protein-coding genes in domestic Bactrian camels. The estimated dN/dS < 1 in the concatenated protein-coding genes suggested purifying selection as driving force for shaping mitogenome diversity in camels. Additional analyses of the functional divergence in amino acid changes between species-specific lineages indicated fixed substitutions in various genes, with radical effects on the physicochemical properties of the protein products. The evolutionary time estimates revealed a divergence between domestic and wild Bactrian camels around 1.1 [0.58-1.8] million years ago (mya). This has major implications for the conservation and management of the critically endangered wild species, Camelus ferus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.