ArticleMolecular biology of the cell2017
Destabilization of the replication fork protection complex disrupts meiotic chromosome segregation.
Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Separation-of-Function Alleles ofBiomolecules · 2025Article
- Measuring Cell Dimensions in Fission Yeast Using Machine Learning.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Quality Control Method and Device for Producing Agarose Micropads.microPublication biology · 2024Article
- Photo Phenosizer, a rapid machine learning-based method to measure cell dimensions in fission yeast.microPublication biology · 2022Article
- A visual atlas of meiotic protein dynamics in living fission yeast.Open biology · 2021Article
- Term Matrix: a novel Gene Ontology annotation quality control system based on ontology term co-annotation patterns.Open biology · 2020Article
- Translesion synthesis polymerases contribute to meiotic chromosome segregation and cohesin dynamics inJournal of cell science · 2020Article
- Checkpoint Regulation of Nuclear Tos4 Defines S Phase Arrest in Fission Yeast.G3 (Bethesda, Md.) · 2020Article
- Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy.Journal of visualized experiments : JoVE · 2019Article
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Authors and funding
2 authors.
Funding
Abstract
The replication fork protection complex (FPC) coordinates multiple processes that are crucial for unimpeded passage of the replisome through various barriers and difficult to replicate areas of the genome. We examine the function of Swi1 and Swi3, fission yeast's primary FPC components, to elucidate how replication fork stability contributes to DNA integrity in meiosis. We report that destabilization of the FPC results in reduced spore viability, delayed replication, changes in recombination, and chromosome missegregation in meiosis I and meiosis II. These phenotypes are linked to accumulation and persistence of DNA damage markers in meiosis and to problems with cohesion stability at the centromere. These findings reveal an important connection between meiotic replication fork stability and chromosome segregation, two processes with major implications to human reproductive health.
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