Evidence map›Paper›PMID 28855352›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2017

Low-Dose Cyclophosphamide Induces Antitumor T-Cell Responses, which Associate with Survival in Metastatic Colorectal Cancer.

Martin Scurr, Tom Pembroke, Anja Bloom, David Roberts, Amanda Thomson, Kathryn Smart, Hayley Bridgeman, Richard Adams, Alison Brewster, Robert Jones and 6 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04895761 (Phase Ib Study of Neoadjuvant DPX-Survivac, Aromatase Inhibition, and With/Without Radiotherapy or Cyclophosphamide in HR+HER2- Breast Cancer), which is not on this map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04895761 phase1active not recruitingnot on this mapstarted 2021, after this paper: background citation

Phase Ib Study of Neoadjuvant DPX-Survivac, Aromatase Inhibition, and With/Without Radiotherapy or Cyclophosphamide in HR+HER2- Breast Cancer

TypeinterventionalSponsorProvidence Health & ServicesRan2021 to 2026Enrolled6ConditionsBreast CancerArmsDPX-Survivac, Letrozole 2.5mg, Cyclophosphamide 50mg, XRT 10Gy x2
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  9. Focal radiotherapy improves CAR T cell therapy targeting prostate cancer.bioRxiv : the preprint server for biology · 2026
    Article
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  13. NK Cell Activation by Platinum Boosts Immunotherapy in HRAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  14. Review
  15. Article
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Martin ScurrDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
Tom PembrokeDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
Anja BloomDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
David RobertsDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
Amanda ThomsonDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
Kathryn SmartDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
Hayley BridgemanDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
Richard AdamsVelindre NHS Trust, Whitchurch, Cardiff, United Kingdom.
Alison BrewsterVelindre NHS Trust, Whitchurch, Cardiff, United Kingdom.
Robert JonesVelindre NHS Trust, Whitchurch, Cardiff, United Kingdom.
Sarah GwynneSouth West Wales Cancer Centre, Swansea, United Kingdom.
Daniel BlountOxford BioMedica plc., Oxford, United Kingdom.
Richard HarropOxford BioMedica plc., Oxford, United Kingdom.
Robert HillsCancer Trials Unit (Translational Statistics), Cardiff University, Cardiff, United Kingdom.
Awen GallimoreDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom.
Andrew GodkinDivision of Infection and Immunity, Cardiff University, Cardiff, United Kingdom. godkinaj@cardiff.ac.uk.
Cardiff University · GB

Funding

Cancer Research UK 21200Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic Agents, AlkylatingAntineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsCyclophosphamideDisease ProgressionFemaleHumansImmunomodulationMaleNeoplasm MetastasisNeoplasm StagingRetreatmentT-LymphocytesTreatment OutcomeAntineoplastic Agents, AlkylatingCyclophosphamide

Identifiers

PMID28855352
PMCPMC5769815
OpenAlexW2751623946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.