Evidence map›Paper›PMID 28855348›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40.

David J Messenheimer, Shawn M Jensen, Michael E Afentoulis, Keith W Wegmann, Zipei Feng, David J Friedman, Michael J Gough, Walter J Urba, Bernard A Fox

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

181 citing papers in PubMed.

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  8. CD8Nature reviews. Cardiology · 2026
    Review
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  20. Timely administration of drug combination improves chemoimmunotherapy of an immune-cold tumor.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article

121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David J MessenheimerEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon.
Shawn M JensenEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon.
Michael E AfentoulisEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon.
Keith W WegmannEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon.
Zipei FengEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon.
David J FriedmanEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon.
Michael J GoughEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon.
Walter J UrbaEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon.
Bernard A FoxEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Cancer Center, Portland, Oregon. foxb@foxlab.org.

Funding

INTERACTIONS AT THE MICROBE/HOST INTERFACET32AI007472 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LANDFEAR, SCOTT M · 1995 to 2019
$6.7M
MECHANISMS THAT REGULATE TUMOR SPECIFIC IMMUNE RESPONSESR01CA080964 · NCI · PROVIDENCE PORTLAND MEDICAL CENTER · PI FOX, BERNARD A · 1999 to 2014
$3.3M
NCI NIH HHS R01 CA080964NIAID NIH HHS T32 AI007472
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunotherapyMolecular Targeted TherapyAnimalsAntineoplastic Agents, ImmunologicalAntineoplastic Combined Chemotherapy ProtocolsCytokinesDisease Models, AnimalFemaleHumansImmunophenotypingLymphocyte CountLymphocytes, Tumor-InfiltratingMiceMice, TransgenicProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellAntineoplastic Agents, ImmunologicalCytokinesProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellReceptors, OX40

Identifiers

PMID28855348
PMCPMC5641261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.