Evidence map›Paper›PMID 28855298›Full record

ArticleJournal of neurophysiology2017

Spinal BDNF-induced phrenic motor facilitation requires PKCθ activity.

Ibis M Agosto-Marlin, Gordon S Mitchell

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders.International journal of molecular sciences · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Cervical spinal 5-HTJournal of applied physiology (Bethesda, Md. : 1985) · 2019
    Article
  11. Circulatory control of phrenic motor plasticity.Respiratory physiology & neurobiology · 2019
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ibis M Agosto-MarlinDepartment of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin; and.
Gordon S MitchellDepartment of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin; and gsmitche@phhp.ufl.edu.
University of Wisconsin–Madison · US

Funding

Respiratory Plasticity and Spinal Cord InjuryR01HL069064 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL069064
6 · The paper itself

Abstract

Spinal brain-derived neurotrophic factor (BDNF) is necessary and sufficient for certain forms of long-lasting phrenic motor facilitation (pMF). BDNF elicits pMF by binding to its high-affinity receptor, tropomyosin receptor kinase B (TrkB), on phrenic motor neurons, potentially activating multiple downstream signaling cascades. Canonical BDNF/TrkB signaling includes the

Indexed as

AnimalsBrain-Derived Neurotrophic FactorCatheters, IndwellingEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesMaleMAP Kinase Kinase KinasesMotor NeuronsPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPhrenic NerveProtein Kinase C-deltaProto-Oncogene Proteins c-aktRats, Sprague-DawleySignal TransductionSpinal CordBrain-Derived Neurotrophic FactorEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesMAP Kinase Kinase KinasesPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtein Kinase C-deltaProto-Oncogene Proteins c-aktBDNFMEK/ERKmotor neuronphrenic motor facilitationPI3K/AktPLC/PKCθrespiratory plasticity

Identifiers

PMID28855298
PMCPMC5675902
OpenAlexW2752690476

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.