ArticleJournal of neurophysiology2017
Effect of M-current modulation on mammalian vestibular responses to transient head motion.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Inhibition of Ionic Currents by Fluoxetine in Vestibular Calyces in Different Epithelial Loci.International journal of molecular sciences · 2024Article
- Article
- Effects of Several Therapeutic Agents on Mammalian Vestibular Function: Meclizine, Diazepam, and JNJ7777120.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Effects of Neurod1 Expression on Mouse and Human Schwannoma Cells.The Laryngoscope · 2021Article
- Cholinergic Modulation of Membrane Properties of Calyx Terminals in the Vestibular Periphery.Neuroscience · 2021Article
- Dopaminergic Inhibition of NaFrontiers in neuroscience · 2021Article
- Activation of GABAJournal of neurophysiology · 2020Article
- A novel intracochlear injection method for rapid drug delivery to vestibular end organs.Journal of neuroscience methods · 2020Article
- A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.Journal of neurophysiology · 2020Review
- Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations.Nature communications · 2020Article
- Efferent Inputs Are Required for Normal Function of Vestibular Nerve Afferents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Enhanced Activation of HCN Channels Reduces Excitability and Spike-Timing Regularity in Maturing Vestibular Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Semicircular canal biomechanics in health and disease.Journal of neurophysiology · 2019Review
- Spontaneous and Acetylcholine Evoked Calcium Transients in the Developing Mouse Utricle.Frontiers in cellular neuroscience · 2019Article
- Neuropharmacological Targets for Drug Action in Vestibular Sensory Pathways.Journal of audiology & otology · 2017Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The precise role and mechanisms underlying efferent modulation of peripheral vestibular afferent function are not well understood in mammals. Clarifying the details of efferent action may lead to new strategies for clinical management of debilitating disturbances in vestibular and balance function. Recent evidence in turtle indicates that efferent modulation of M-currents is likely one mechanism for modifying afferent discharge. M-currents depend in part on KCNQ potassium conductances (Kv7), which can be adjusted through efferent activation of M1, M3, and/or M5 muscarinic acetylcholine receptors (mAChRs). How KCNQ channels and altered M-currents affect vestibular afferent function in vivo is unclear, and whether such a mechanism operates in mammals is unknown. In this study we used the KCNQ antagonist XE991 and the KCNQ activator retigabine in anesthetized mice to evaluate the effects of M-current modulation on peripheral vestibular responses to transient head motion. At low doses of XE991, responses were modestly enhanced, becoming larger in amplitude and shorter in latency. Higher doses of XE991 produced transient response enhancement, followed by steady-state suppression where latencies and thresholds increased and amplitudes decreased. Retigabine produced opposite effects. Auditory function was also impacted, based on results of companion auditory brain stem response testing. We propose that closure of KCNQ channels transforms vestibular afferent behavior by suppressing responses to transient high-frequency stimuli while simultaneously enhancing responses to sustained low-frequency stimulation. Our results clearly demonstrate that KCNQ channels are critical for normal mammalian vestibular function and suggest that efferent action may utilize these mechanisms to modulate the dynamic characteristics and gain of vestibular afferent responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.