ReviewJournal of neurophysiology2017
Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.
Review in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 61 citations in OpenAlex.
- Rebuilding spinal circuit function after spinal cord injury through a patient-specific interneuron precision model.Frontiers in neuroscience · 2026Article
- Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury.Neural regeneration research · 2025Article
- Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.eLife · 2024Article
- Review
- Potential contribution of spinal interneurons to the etiopathogenesis of amyotrophic lateral sclerosis.Frontiers in neuroscience · 2024Review
- Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons.Journal of neurophysiology · 2023Article
- A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury.IBRO neuroscience reports · 2023Article
- Chx10+V2a interneurons in spinal motor regulation and spinal cord injury.Neural regeneration research · 2023Review
- Enrichment of human embryonic stem cell-derived V3 interneurons using an Nkx2-2 gene-specific reporter.Scientific reports · 2023Article
- Lumbar V3 interneurons provide direct excitatory synaptic input onto thoracic sympathetic preganglionic neurons, linking locomotor, and autonomic spinal systems.Frontiers in neural circuits · 2023Article
- Hindlimb muscle representations in mouse motor cortex defined by viral tracing.Frontiers in neuroanatomy · 2023Article
- The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice.eLife · 2022Article
- Article
- Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties.Frontiers in neural circuits · 2022Article
- Tools for efficient analysis of neurons in a 3D reference atlas of whole mouse spinal cord.Cell reports methods · 2021Article
- The Temporal Mechanisms Guiding Interneuron Differentiation in the Spinal Cord.International journal of molecular sciences · 2021Review
- Somatosensory corticospinal tract axons sprout within the cervical cord following a dorsal root/dorsal column spinal injury in the rat.The Journal of comparative neurology · 2020Article
- Neurotransmitters and Motoneuron Contacts of Multifunctional and Behaviorally Specialized Turtle Spinal Cord Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Crossed activation of thoracic trunk motoneurons by medullary reticulospinal neurons.Journal of neurophysiology · 2019Article
- Hierarchical control of locomotion by distinct types of spinal V2a interneurons in zebrafish.Nature communications · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Mapping the expression of transcription factors in the mouse spinal cord has identified ten progenitor domains, four of which are cardinal classes of molecularly defined, ventrally located interneurons that are integrated in the locomotor circuitry. This review focuses on the properties of these interneuronal populations and their contribution to hindlimb locomotor central pattern generation. Interneuronal populations are categorized based on their excitatory or inhibitory functions and their axonal projections as predictors of their role in locomotor rhythm generation and coordination. The synaptic connectivity and functions of these interneurons in the locomotor central pattern generators (CPGs) have been assessed by correlating their activity patterns with motor output responses to rhythmogenic neurochemicals and sensory and descending fibers stimulations as well as analyzing kinematic gait patterns in adult mice. The observed complex organization of interneurons in the locomotor CPG circuitry, some with seemingly similar physiological functions, reflects the intricate repertoire associated with mammalian motor control and is consistent with high transcriptional heterogeneity arising from cardinal interneuronal classes. This review discusses insights derived from recent studies to describe innovative approaches and limitations in experimental model systems and to identify missing links in current investigational enterprise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.