Evidence map›Paper›PMID 28855253›Full record

ArticleThe Journal of biological chemistry2017

Phosphorylation of mycobacterial phosphodiesterase by eukaryotic-type Ser/Thr kinase controls its two distinct and mutually exclusive functionalities.

Neha Malhotra, Subramanian Karthikeyan, Pradip K Chakraborti

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Rv2577 ofFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Neha MalhotraFrom the Council of Scientific and Industrial Research-Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, India.
Subramanian KarthikeyanFrom the Council of Scientific and Industrial Research-Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, India.
Pradip K ChakrabortiFrom the Council of Scientific and Industrial Research-Institute of Microbial Technology, Sector 39A, Chandigarh 160 036, India pradip@imtech.res.in pkchakraborti@jamiahamdard.ac.in.
Institute of Microbial Technology · INCouncil of Scientific and Industrial Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphorylation-mediated negative feedback regulation of cAMP levels by phosphodiesterase is well-established in eukaryotic cells. However, such a mechanism remains unexplored in prokaryotes. We report here the involvement of eukaryotic-type Ser/Thr kinases, particularly PknA in trans-phosphorylating phosphodiesterase from

Indexed as

Bacterial ProteinsCell WallEscherichia coliGene Knockdown TechniquesGenetic Complementation TestMycobacterium tuberculosisPhosphoric Diester HydrolasesPhosphorylationProtein Serine-Threonine KinasesBacterial ProteinsPhosphoric Diester HydrolasesPknA protein, Mycobacterium tuberculosisProtein Serine-Threonine Kinasescyclic AMP (cAMP)enzyme kineticsintracellular traffickingmutagenesispost translational modificationpost-translational modification (PTM)signal transduction

Identifiers

PMID28855253
PMCPMC5655513
OpenAlexW2752177277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.