ArticleThe Journal of experimental medicine2017
RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
78 citing papers in PubMed.
- HIGH DOSE GAMMAHERPESVIRUS INFECTION IN MACROPHAGES RESULTS IN INFLAMMATORY MULTIMODAL CELL DEATH.bioRxiv : the preprint server for biology · 2026Article
- Exosomal export of activated CASPASE-8 is linked to the prevention of TNF-induced cytotoxicity.Nature communications · 2026Article
- PANoptosis as a drug discovery framework: integrating cell death architecture with clinical translation.Genes and immunity · 2026Review
- Shigella type-III secretion system effectors counteract the induction of host inflammation and cell death.The EMBO journal · 2025Article
- Targeting tumor intrinsic TAK1 engages TNF-α-driven cell death through distinct mechanisms and enhances cancer immunotherapy.Cell death & disease · 2025Article
- Innate detection ofbioRxiv : the preprint server for biology · 2025Article
- Article
- Raver1 linksProceedings of the National Academy of Sciences of the United States of America · 2025Article
- miRNA-Targeted Vaccines: A Promising Approach for Viral Attenuation and Immunogenicity Enhancement.Current gene therapy · 2025Review
- Targeting TNFR1-driven necroptosis in breast cancer.EXCLI journal · 2025Review
- Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity.PLoS pathogens · 2025Review
- TLR priming licenses NAIP inflammasome activation by immunoevasive ligands.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Non-canonical autophosphorylation of RIPK1 drives timely pyroptosis to control Yersinia infection.Cell reports · 2024Article
- Yersinia infection induces glucose depletion and AMPK-dependent inhibition of pyroptosis in mice.Nature microbiology · 2024Article
- Blockade of IKK signaling induces RIPK1-independent apoptosis in human macrophages.PLoS pathogens · 2024Article
- Caspase-8 activity mediates TNFα production and restrictsInfection and immunity · 2024Article
- Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions.Biomedicines · 2024Review
- Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages.Cell death & disease · 2024Article
- Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics.Cell host & microbe · 2024Review
- RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis.Cell death and differentiation · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Lance W PetersonDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.ORCID http://orcid.org/0000-0003-2458-6678
Naomi H PhilipDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.
Alexandra DeLaneyDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.
Meghan A Wynosky-DolfiDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.
Kendra AsklofDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.
Falon GrayDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.
Ruth ChoaDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.ORCID http://orcid.org/0000-0002-4798-7565
Elisabet BjanesDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.
Elisabeth L BuzaDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.
Baofeng HuDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA.ORCID http://orcid.org/0000-0002-8641-6693
Christopher P DillonDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN.
Douglas R GreenDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN.
Scott B BergerHost Defense Discovery Performance Unit, Infectious Disease Therapy Area Unit, GlaxoSmithKline, Collegeville, PA.
Peter J GoughHost Defense Discovery Performance Unit, Infectious Disease Therapy Area Unit, GlaxoSmithKline, Collegeville, PA.ORCID http://orcid.org/0000-0002-5110-9300
John BertinPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA.
Igor E BrodskyDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA ibrodsky@vet.upenn.edu.ORCID http://orcid.org/0000-0001-7970-872X
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007170 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BRASS, LAWRENCE F · 1985 to 2022
$54.0MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5MSurvival Function of the Fadd-Caspase-8-Flip ComplexR01AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GREEN, DOUGLAS R. · 1999 to 2016
$6.3MTRAINING PROGRAM/RHEUMATIC DISEASEST32AR007442 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BEHRENS, EDWARD M, MERKEL, PETER A · 1986 to 2018
$5.8MSurvival Function of the Fadd-Caspase-8-Flip Complex - MERIT ExtensionR37AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2017 to 2026
$4.5MDefining the non-apoptotic role of Caspase-8 activity in anti-bacterial immune defenseR01AI128530 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2017 to 2021
$2.0MModulation of Inflammasome Activation by YersiniaR01AI103062 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2013 to 2016
$1.7MDissecting the mechanism of RIPK1 kinase-dependent cell death in control of Yersinia infectionR21AI125924 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2016 to 2017
$459kRole of Caspase-8 in Yersinia virulence and host defenseR21AI109267 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2014 to 2015
$440kNIAID NIH HHS R01 AI044828NIAID NIH HHS R01 AI103062NIAID NIH HHS R01 AI128530NIAID NIH HHS R21 AI109267NIAID NIH HHS R21 AI125924NIAID NIH HHS R37 AI044828NIAMS NIH HHS T32 AR007442NIDDK NIH HHS P30 DK050306
Abstract
Many pathogens deliver virulence factors or effectors into host cells in order to evade host defenses and establish infection. Although such effector proteins disrupt critical cellular signaling pathways, they also trigger specific antipathogen responses, a process termed "effector-triggered immunity." The Gram-negative bacterial pathogen
Indexed as
AnimalsApoptosisCytokinesDisease ResistanceHost-Pathogen InteractionsImmunity, InnateMacrophagesMAP Kinase Signaling SystemMice, Inbred C57BLMice, KnockoutModels, ImmunologicalNF-kappa BReceptor-Interacting Protein Serine-Threonine KinasesSignal TransductionSurvival AnalysisYersinia pseudotuberculosisCytokinesNF-kappa BReceptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouse
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LicenceCC BY-NC-SA
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.