Evidence map›Paper›PMID 28855239›Full record

Trial reportDiabetes care2017

Closed-Loop Control During Intense Prolonged Outdoor Exercise in Adolescents With Type 1 Diabetes: The Artificial Pancreas Ski Study.

Marc D Breton, Daniel R Cherñavvsky, Gregory P Forlenza, Mark D DeBoer, Jessica Robic, R Paul Wadwa, Laurel H Messer, Boris P Kovatchev, David M Maahs

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02604524 (Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM), which is not on this map. Cited by 69 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 6 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02604524 nacompletednot on this map

Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp

TypeinterventionalSponsorDaniel Chernavvsky, MD, CRCRan2016 to 2016Enrolled32ConditionsType 1 Diabetes MellitusArmsClosed-Loop Control, Sensor Augmented Pump Therapy
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 6 syntheses or guidelines pooled it, 177 citations in OpenAlex.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marc D BretonCenter for Diabetes Technology, University of Virginia, Charlottesville, VA mb6nt@virginia.edu.ORCID 0000-0001-7645-2693
Daniel R CherñavvskyCenter for Diabetes Technology, University of Virginia, Charlottesville, VA.
Gregory P ForlenzaBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO.ORCID 0000-0003-3607-9788
Mark D DeBoerCenter for Diabetes Technology, University of Virginia, Charlottesville, VA.
Jessica RobicCenter for Diabetes Technology, University of Virginia, Charlottesville, VA.
R Paul WadwaBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO.
Laurel H MesserBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO.
Boris P KovatchevCenter for Diabetes Technology, University of Virginia, Charlottesville, VA.
David M MaahsBarbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO.
University of Virginia · USUniversity of Colorado Denver · US

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Models, signals, and distributed bio-behavioral control of exercise in diabetesDP3DK106826 · NIDDK · UNIVERSITY OF VIRGINIA · PI BRETON, MARC D · 2015 to 2015
$3.0M
NIDDK NIH HHS DP3 DK106826NIDDK NIH HHS P30 DK116074
6 · The paper itself

Abstract

objectiveIntense exercise is a major challenge to the management of type 1 diabetes (T1D). Closed-loop control (CLC) systems (artificial pancreas) improve glycemic control during limited intensity and short duration of physical activity (PA). However, CLC has not been tested during extended vigorous outdoor exercise common among adolescents. RESEARCH DESIGN AND

methodsSkiing presents unique metabolic challenges: intense prolonged PA, cold, altitude, and stress/fear/excitement. In a randomized controlled trial, 32 adolescents with T1D (ages 10-16 years) participated in a 5-day ski camp (∼5 h skiing/day) at two sites: Wintergreen, VA, and Breckenridge, CO. Participants were randomized to the University of Virginia CLC system or remotely monitored sensor-augmented pump (RM-SAP). The CLC and RM-SAP groups were coarsely paired by age and hemoglobin A

resultsCompared with physician-monitored open loop, percent time in range (70-180 mg/dL) improved using CLC: 71.3 vs. 64.7% (+6.6% [95% CI 1-12];

conclusionsCLC in adolescents with T1D improved glycemic control and reduced exposure to hypoglycemia during prolonged intensive winter sport activities, despite the added challenges of cold and altitude.

Indexed as

Blood Glucose Self-MonitoringExercisePancreas, ArtificialSkiingAdolescentBlood GlucoseBody Mass IndexChildCold TemperatureColoradoDiabetes Mellitus, Type 1Glycated HemoglobinHumansHypoglycemiaSeasonsTreatment OutcomeBlood GlucoseGlycated Hemoglobin

Identifiers

PMID28855239
PMCPMC5711335
OpenAlexW2752733073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.