ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Baroreflex and neurovascular responses to skeletal muscle mechanoreflex activation in humans: an exercise in integrative physiology.
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The Influence of Exercise and Physical Activity on Autonomic Nervous System Function Measured by Heart Rate Variability in Individuals with Type 1 Diabetes Mellitus-A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Lower-body positive pressure diminishes surface blood flow reactivity during treadmill walking.BMC research notes · 2019Trial
- Autonomic control of cardiac rhythm at the onset of muscle metaboreflex activation following exercise in healthy young and old adults.Physiological reports · 2026Article
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- Determinants of renal flow reserve in adult patients with and without renal artery stenosis.Physiological reports · 2025Article
- Physiological confounders of renal blood flow measurement.Magma (New York, N.Y.) · 2024Review
- Assessment of Maximal Oxygen Uptake (VO2 Max) in Athletes and Nonathletes Assessed in Sports Physiology Laboratory.Cureus · 2024Article
- Comparison of Cardiovascular Response to Lower Body and Whole Body Exercise Among Sedentary Young Adults.Cureus · 2023Article
- Assessment of baroreflex sensitivity during isometric handgrip exercise and oscillatory lower body negative pressure.Journal of Taibah University Medical Sciences · 2023Article
- Concurrent metaboreflex activation increases chronotropic and ventilatory responses to passive leg movement without sex-related differences.European journal of applied physiology · 2023Article
- Interplay between baroreflex sensitivity, obesity and related cardiometabolic risk factors (Review).Experimental and therapeutic medicine · 2022Review
- Autonomic laterality in caloric vestibular stimulation.World journal of cardiology · 2020Article
- Cyclooxygenase inhibition does not impact the pressor response during static or dynamic mechanoreflex activation in healthy decerebrate rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Human renal response to furosemide: Simultaneous oxygenation and perfusion measurements in cortex and medulla.Acta physiologica (Oxford, England) · 2019Article
- Exaggerated cardiovascular responses to muscle contraction and tendon stretch in UCD type-2 diabetes mellitus rats.American journal of physiology. Heart and circulatory physiology · 2019Article
- Influence of Sex, Menstrual Cycle, and Menopause Status on the Exercise Pressor Reflex.Medicine and science in sports and exercise · 2019Review
- The 2019 New Investigator Review Awards.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Assessment of Perfusion and Oxygenation of the Human Renal Cortex and Medulla by Quantitative MRI during Handgrip Exercise.Journal of the American Society of Nephrology : JASN · 2018Article
- Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity.Frontiers in neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Cardiovascular adjustments to exercise resulting in increased blood pressure (BP) and heart rate (HR) occur in response to activation of several neural mechanisms: the exercise pressor reflex, central command, and the arterial baroreflex. Neural inputs from these feedback and feedforward mechanisms integrate in the cardiovascular control centers in the brain stem and modulate sympathetic and parasympathetic neural outflow, resulting in the increased BP and HR observed during exercise. Another specific consequence of the central neural integration of these inputs during exercise is increased sympathetic neural outflow directed to the kidneys, causing renal vasoconstriction, a key reflex mechanism involved in blood flow redistribution during increased skeletal muscle work. Studies in humans have shown that muscle mechanoreflex activation inhibits cardiac vagal outflow, decreasing the sensitivity of baroreflex control of HR. Metabolite sensitization of muscle mechanoreceptors can lead to reduced sensitivity of baroreflex control of HR, with thromboxane being one of the metabolites involved, via greater inhibition of cardiac vagal outflow without affecting baroreflex control of BP or baroreflex resetting. Muscle mechanoreflex activation appears to play a predominant role in causing renal vasoconstriction, both in isolation and in the presence of local metabolites. Limited investigations in older adults and patients with cardiovascular-related disease have provided some insight into how the influence of muscle mechanoreflex activation on baroreflex function and renal vasoconstriction is altered in these populations. However, future research is warranted to better elucidate the specific effect of muscle mechanoreflex activation on baroreflex and neurovascular responses with aging and cardiovascular-related disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.