Evidence map›Paper›PMID 28855174›Full record

ArticleAnnals of the rheumatic diseases2018

The EuroMyositis registry: an international collaborative tool to facilitate myositis research.

James B Lilleker, Jiri Vencovsky, Guochun Wang, Lucy R Wedderburn, Louise Pyndt Diederichsen, Jens Schmidt, Paula Oakley, Olivier Benveniste, Maria Giovanna Danieli, Katalin Danko and 18 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Annals of the rheumatic diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 5 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 5 syntheses or guidelines pooled it, 265 citations in OpenAlex.

  1. Guideline
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  4. Defining anti-synthetase syndrome: a systematic literature review.Clinical and experimental rheumatology · 2022
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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 19 institutions in 14 countries.

James B LillekerDivision of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-9230-4137
Jiri VencovskyInstitute of Rheumatology, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-0851-0713
Guochun WangDepartment of Rheumatology, China-Japan Friendship Hospital, Beijing, China.
Lucy R WedderburnUniversity College London GOS Institute of Child Health and NIHR GOSH Biomedical Research Centre, Great Ormond Street Hospital for Children NHS Trust, London, UK.
Louise Pyndt DiederichsenDepartment of Rheumatology, Odense University Hospital, Odense, Denmark.ORCID http://orcid.org/0000-0002-2581-8912
Jens SchmidtDepartment of Neurology, University Medical Center Göttingen, Göttingen, Germany.
Paula OakleyMyositis UK, Southampton, UK.
Olivier BenvenisteDépartement de Médecine Interne et Immunologie Clinique, Hôpital Pitié-Salpêtrière, AP-HP, UPMC, Paris, France.
Maria Giovanna DanieliClinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche & Ospedali Riuniti, Ancona, Italy.ORCID http://orcid.org/0000-0002-9608-2252
Katalin DankoDivision of Immunology, University of Debrecen, Debrecen, Hungary.
Nguyen Thi Phuong ThuyDepartment of Rheumatology, Bach Mai Hospital, Bach Mai Hospital, Hanoi Medical University, Hanoi, Viet Nam.
Monica Vazquez-Del MercadoDivisión de Medicina Interna, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Helena AnderssonDepartment of Rheumatology, Oslo University Hospital, Oslo, Norway.
Boel De PaepeDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.
Jan L deBleeckerDepartment of Neurology, Ghent University Hospital, Ghent, Belgium.
Britta MaurerDepartment of Rheumatology, University Hospital Zurich, Zurich, Switzerland.
Liza J McCannDepartment of Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Nicolo PipitoneDepartment of Rheumatology, Arcispedale S. Maria Nuova-IRCCS of Reggio Emilia, Reggio Emilia, Italy.
Neil McHughRoyal National Hospital for Rheumatic Diseases, Bath, Bath and North East Somer, UK.
Zoe E BetteridgeRoyal National Hospital for Rheumatic Diseases, Bath, Bath and North East Somer, UK.
Paul NewMRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
Robert G CooperMRC/ARUK Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
William E OllierDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Janine A LambDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Niels Steen KroghZitelab Aps, Copenhagen, Denmark.
Ingrid E LundbergUnit of Rheumatology, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden.
Hector ChinoyDepartment of Rheumatology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, UK.
all EuroMyositis contributors
Manchester Academic Health Science Centre · GBGhent University Hospital · BERoyal National Hospital for Rheumatic Diseases · GBUniversity of Liverpool · GBAlder Hey Children's NHS Foundation Trust · GBAzienda Ospedaliera S.Maria · ITChina-Japan Friendship Hospital · CNGreat Ormond Street Hospital · GBHanoi Medical University · VNInstitute of Rheumatology · CZKarolinska University Hospital · SEMarche Polytechnic University · ITOdense University Hospital · DKOslo University Hospital · NOSorbonne Université · FRUniversidad de Guadalajara · MXUniversitätsmedizin Göttingen · DEUniversity Hospital of Zurich · CHUniversity of Debrecen · HU

Funding

Arthritis Research UK 18474Department of Health RC-PG-0407-10054Medical Research Council G0100594Medical Research Council G0600237Medical Research Council G0900753Medical Research Council G0901461Medical Research Council MR/K002279/1Medical Research Council MR/N003322/1Medical Research Council MR/P020941/1Versus Arthritis 18475Versus Arthritis 20639
6 · The paper itself

Abstract

aimsThe EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data.

methodsCross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated.

resultsOf 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001).Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001).ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases ('V' sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%.

conclusionThis large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.

Indexed as

International CooperationBiomedical ResearchCohort StudiesCross-Sectional StudiesFemaleHealth StatusHumansMaleMyositisPrognosisRegistriesSeverity of Illness IndexSmokingSurveys and QuestionnairesDisease registriesMyositis

Identifiers

PMID28855174
PMCPMC5754739
OpenAlexW2742891217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.