ArticleJournal of the American Heart Association2017
Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low-Normal Ankle-Brachial Index.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Impact of exercise training on muscle mitochondria modifications in older adults: a systematic review of randomized controlled trials.Aging clinical and experimental research · 2022Pooled it
- Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Pooled it
- Enhancing walking performance in patients with peripheral arterial disease: An intervention with ankle-foot orthosis.International journal of cardiology · 2024Article
- Peripheral artery disease diagnosis based on deep learning-enabled analysis of non-invasive arterial pulse waveforms.Computers in biology and medicine · 2024Article
- Cigarette smoking and mitochondrial dysfunction in peripheral artery disease.Vascular medicine (London, England) · 2023Article
- Individual Cofactors and Multisensory Contributions to the Postural Sway of Adults with Diabetes.Brain sciences · 2022Article
- Ankle-Brachial Index and Energy Production in People Without Peripheral Artery Disease: The BLSA.Journal of the American Heart Association · 2022Article
- Interventional- and amputation-stage muscle proteomes in the chronically threatened ischemic limb.Clinical and translational medicine · 2022Article
- Mitochondrial DNA copy number and heteroplasmy load correlate with skeletal muscle oxidative capacity by P31 MR spectroscopy.Aging cell · 2021Article
- Diffusion tensor imaging indices of acute muscle damage are augmented after exercise in peripheral arterial disease.European journal of applied physiology · 2021Article
- Associations of Peripheral Artery Disease With Calf Skeletal Muscle Mitochondrial DNA Heteroplasmy.Journal of the American Heart Association · 2020Article
- The Rise of Mitochondria in Peripheral Arterial Disease Physiopathology: Experimental and Clinical Data.Journal of clinical medicine · 2019Review
- The exercise pressor reflex and active OPhysiological reports · 2019Article
- Subclinical Longitudinal Change in Ankle-Brachial Index With Aging in a Community-Dwelling Population Is Associated With Central Arterial Stiffening.Journal of the American Heart Association · 2019Article
- Oxygen availability and skeletal muscle oxidative capacity in patients with peripheral artery disease: implications from in vivo and in vitro assessments.American journal of physiology. Heart and circulatory physiology · 2018Article
- Cardiovascular Magnetic Resonance in the Oncology Patient.JACC. Cardiovascular imaging · 2018Review
- Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance.Vascular medicine (London, England) · 2018Article
- Searching for a mitochondrial root to the decline in muscle function with ageing.Journal of cachexia, sarcopenia and muscle · 2018Article
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundLower muscle mitochondrial energy production may contribute to impaired walking endurance in patients with peripheral arterial disease. A borderline ankle-brachial index (ABI) of 0.91 to 1.10 is associated with poorer walking endurance compared with higher ABI. We hypothesized that in the absence of peripheral arterial disease, lower ABI is associated with lower mitochondrial energy production. METHODS AND
resultsWe examined 363 men and women participating in the Baltimore Longitudinal Study of Aging with an ABI between 0.90 and 1.40. Muscle mitochondrial energy production was assessed by post-exercise phosphocreatine recovery rate constant (
conclusionsAn ABI of 0.90 to 1.10 is associated with lower mitochondrial energy production compared with an ABI of 1.11 to 1.40. These data demonstrate adverse associations of lower ABI values with impaired mitochondrial activity even within the range of a clinically accepted definition of a normal ABI. Further study is needed to determine whether interventions in persons with ABIs of 0.90 to 1.10 can prevent subsequent functional decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.