ArticleAmerican journal of physiology. Cell physiology2017
Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.
Article in American journal of physiology. Cell physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Rho-kinase inhibition improves haemodynamic responses and circulating ATP during hypoxia and moderate intensity handgrip exercise in healthy older adults.The Journal of physiology · 2022Trial
- Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025Review
- Modeling Reactive Hyperemia to Better Understand and Assess Microvascular Function: A Review of Techniques.Annals of biomedical engineering · 2023Review
- Mechanosensitive Pannexin 1 Activity Is Modulated by Stomatin in Human Red Blood Cells.International journal of molecular sciences · 2022Article
- The inhibition of glucose uptake to erythrocytes: microwave dielectric response.European biophysics journal : EBJ · 2022Article
- Possible role of pannexin 1 channels and purinergic receptors in the pathogenesis and mechanism of action of SARS-CoV-2 and therapeutic potential of targeting them in COVID-19.Life sciences · 2022Review
- The role of globins in cardiovascular physiology.Physiological reviews · 2022Review
- Pannexin 1 as a driver of inflammation and ischemia-reperfusion injury.Purinergic signalling · 2021Review
- Purinergic interplay between erythrocytes and platelets in diabetes-associated vascular dysfunction.Purinergic signalling · 2021Review
- Article
- Pannexin 1 channels control the hemodynamic response to hypoxia by regulating OAmerican journal of physiology. Heart and circulatory physiology · 2021Article
- Generation and Export of Red Blood Cell ATP in Health and Disease.Frontiers in physiology · 2021Review
- Cellular microdomains for nitric oxide signaling in endothelium and red blood cells.Nitric oxide : biology and chemistry · 2020Review
- Reduced deformability contributes to impaired deoxygenation-induced ATP release from red blood cells of older adult humans.The Journal of physiology · 2019Article
- Dietary Fatty Acids Affect Red Blood Cell Membrane Composition and Red Blood Cell ATP Release in Dairy Cows.International journal of molecular sciences · 2019Article
- Red Blood Cell Deformability, Vasoactive Mediators, and Adhesion.Frontiers in physiology · 2019Review
- Connexins and Pannexins in Vascular Function and Disease.International journal of molecular sciences · 2018Review
- A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome.Redox biology · 2018Article
- Revisiting multimodal activation and channel properties of Pannexin 1.The Journal of general physiology · 2018Review
- Effects of Hypoxia on Erythrocyte Membrane Properties-Implications for Intravascular Hemolysis and Purinergic Control of Blood Flow.Frontiers in physiology · 2017Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle. In ex vivo settings RBCs have been shown to release ATP in response to a number of stimuli, including stimulation of adrenergic receptors. Further evidence suggested that ATP release from RBCs was dependent on activation of adenylate cyclase (AC)/cyclic adenosine monophosphate (cAMP)-dependent pathways and involved the pannexin 1 (Panx1) channel. Here we show that RBCs express Panx1 and confirm its absence in Panx1 knockout (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.