ArticleBMC veterinary research2017
Critically appraised topic on adverse food reactions of companion animals (4): can we diagnose adverse food reactions in dogs and cats with in vivo or in vitro tests?
Article in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- A prospective double-blinded study evaluating threshold doses of dietary allergens that trigger adverse food reactions in dogs, and time to flare after exposure.Frontiers in veterinary science · 2026Article
- Black Soldier Fly (Veterinary sciences · 2025Article
- Evaluation of hydrolyzed salmon and hydrolyzed poultry feather diets in restrictive diet trials for diagnosis of food allergies in pruritic dogs.Frontiers in veterinary science · 2025Article
- The Impact of a Hypoallergenic Diet on the Control of Oral Lesions in Cats: A Case Report.Animals : an open access journal from MDPI · 2024Article
- Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs.Veterinary sciences · 2023Article
- Enterocytes in Food Hypersensitivity Reactions.Animals : an open access journal from MDPI · 2021Article
- The usefulness of a hydrolysed fish and rice starch elimination diet for the diagnosis of adverse food reactions in cats: an open clinical trial.Veterinary dermatology · 2021Article
- Detection of DNA from undeclared animal species in commercial canine and feline raw meat diets using qPCR.The Canadian veterinary journal = La revue veterinaire canadienne · 2020Article
- Critically appraised topic on adverse food reactions of companion animals (9): time to flare of cutaneous signs after a dietary challenge in dogs and cats with food allergies.BMC veterinary research · 2020Review
- Review of critically appraised topics on adverse food reactions of companion animals.The Canadian veterinary journal = La revue veterinaire canadienne · 2020Article
- Assessment of dog owners' knowledge relating to the diagnosis and treatment of canine food allergies.The Canadian veterinary journal = La revue veterinaire canadienne · 2019Article
- Cornstarch is less allergenic than corn flour in dogs and cats previously sensitized to corn.BMC veterinary research · 2018Article
- DNA and Protein Analyses to Confirm the Absence of Cross-Contamination and Support the Clinical Reliability of Extensively Hydrolysed Diets for Adverse Food Reaction-Pets.Veterinary sciences · 2018Article
- Developments in small animal veterinary dermatology.The Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- Atopic dermatitis in cats and dogs: a difficult disease for animals and owners.Clinical and translational allergy · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gold standard to diagnose adverse food reactions (AFRs) in the dog and cat is currently an elimination diet with subsequent provocation trials. However, those trials are inconvenient and client compliance can be low. Our objective was to systematically review the literature to evaluate in vivo and in vitro tests used to diagnose AFR in small animals.
resultsWe searched three databases (CAB Abstracts, MEDLINE and Web of Science) for pertinent references on September 16, 2016. Among 71, 544 and 41 articles found in the CAB Abstract, MEDLINE and Web of Science databases, respectively, we selected 22 articles and abstracts from conference proceedings that reported data usable for evaluation of tests for AFR. Serum tests for food-specific IgE and IgG, intradermal testing with food antigens, lymphocyte proliferation tests, fecal food-specific IgE, patch, gastroscopic, and colonoscopic testing were evaluated.
conclusionsTesting for serum food-specific IgE and IgG showed low repeatability and, in dogs, a highly variable accuracy. In cats, the accuracy of testing for food-specific IgE was low. Lymphocyte proliferation tests were more frequently positive and more accurate in animals with AFR, but, as they are more difficult to perform, they remain currently a research tool. All other reported tests were only evaluated by individual studies with small numbers of animals. Negative patch test reactions have a very high negative predictability in dogs and could enable a choice of ingredients for the elimination diet in selected patients. Gastroscopic and colonoscopic testing as well as food-specific fecal IgE or food-specific serum IgG measurements appear less useful. Currently, the best diagnostic procedure to identify AFRs in small animals remains an elimination diet with subsequent provocation trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.