ArticleBMC genomics2017
Omics data reveal the unusual asexual-fruiting nature and secondary metabolic potentials of the medicinal fungus Cordyceps cicadae.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 43 citations in OpenAlex.
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- A Review of Genomic, Transcriptomic, and Proteomic Applications in Edible Fungi Biology: Current Status and Future Directions.Journal of fungi (Basel, Switzerland) · 2025Review
- The whole genome sequence of Cordyceps cicadae - an edible and potential medicinal fungus.Molecular genetics and genomics : MGG · 2025Article
- Genome Sequence, Comparative Genome Analysis, and Expression Profiling of the Chitinase GH18 Gene Family inInternational journal of molecular sciences · 2025Article
- Fungal evasion ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multi-omics insights into growth and fruiting body development in the entomopathogenic fungusIMA fungus · 2025Article
- Exploiting the roles of nitrogen sources for HEA increment inFrontiers in microbiology · 2024Article
- Unique Bioactives from Zombie Fungus (Nutrients · 2023Review
- Two new diketopiperazines from the Cordyceps fungus Samsoniella sp. XY4.The Journal of antibiotics · 2023Article
- A bacterial-like Pictet-Spenglerase drives the evolution of fungi to produce β-carboline glycosides together with separate genes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- GPI-Anchored Protein HomologJournal of fungi (Basel, Switzerland) · 2022Article
- Genomic Sequence and Transcriptome Analysis of the Medicinal Fungus Keithomyces neogunnii.Genome biology and evolution · 2022Article
- Target Activity ofJournal of fungi (Basel, Switzerland) · 2020Article
- Secondary metabolites from hypocrealean entomopathogenic fungi: genomics as a tool to elucidate the encoded parvome.Natural product reports · 2020Review
- Production of Diverse Beauveriolide Analogs in Closely Related Fungi: a Rare Case of Fungal Chemodiversity.mSphere · 2020Article
- Review
- Genomic Features ofPathogens (Basel, Switzerland) · 2020Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAscomycete Cordyceps species have been using as valued traditional Chinese medicines. Particularly, the fruiting bodies of Cordyceps cicadae (syn. Isaria cicadae) have long been utilized for the treatment of chronic kidney disease. However, the genetics and bioactive chemicals in this fungus have been largely unexplored.
resultsIn this study, we performed comprehensive omics analyses of C. cicadae, and found that, in contrast to other Cordyceps fungi, C. cicadae produces asexual fruiting bodies with the production of conidial spores instead of the meiotic ascospores. Genome sequencing and comparative genomic analysis indicate that the protein families encoded by C. cicadae are typical of entomopathogenic fungi, including the expansion of proteases and chitinases for targeting insect hosts. Interestingly, we found that the MAT1-2 mating-type locus of the sequenced strain contains an abnormally truncated MAT1-1-1 gene. Gene deletions revealed that asexual fruiting of C. cicadae is independent of the MAT locus control. RNA-seq transcriptome data also indicate that, compared to growth in a liquid culture, the putative genes involved in mating and meiosis processes were not up-regulated during fungal fruiting, further supporting asexual reproduction in this fungus. The genome of C. cicadae encodes an array of conservative and divergent gene clusters for secondary metabolisms. Based on our analysis, the production of known carcinogenic metabolites by this fungus could be potentially precluded. However, the confirmed production of oosporein raises health concerns about the frequent consumption of fungal fruiting bodies.
conclusionsThe results of this study expand our knowledge of fungal genetics that asexual fruiting can occur independent of the MAT locus control. The obtained genomic and metabolomic data will benefit future investigations of this fungus for medicinal uses.
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