ArticleGenome biology and evolution2017
Genomic Epidemiology of NDM-1-Encoding Plasmids in Latin American Clinical Isolates Reveals Insights into the Evolution of Multidrug Resistance.
Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- The Emergence ofAntibiotics (Basel, Switzerland) · 2025Article
- The Therapeutic Potential of Cefiderocol in the Treatment of Multidrug-Resistant Gram-Negative Bacteria: A Narrative Review.Journal of clinical medicine · 2025Review
- Emergence and dissemination ofMicrobiology spectrum · 2025Article
- New Insights inAntibiotics (Basel, Switzerland) · 2025Article
- Emergence of NDM-1 on IncR-IncFIA (HI1) plasmid in carbapenem-resistantFrontiers in microbiology · 2025Article
- Analysis ofAntimicrobial agents and chemotherapy · 2024Article
- Genomic Characterization of a Clinical NDM-1-ProducingMicroorganisms · 2024Article
- Molecular epidemiology of carbapenem-resistant gram-negative bacilli in Ecuador.BMC infectious diseases · 2024Article
- Molecular characterization of carbapenemase-producing Enterobacterales in a tertiary hospital in Lima, Peru.Microbiology spectrum · 2024Article
- Co-integrate Col3mMicrobiology spectrum · 2023Article
- Detection of NDM-1 and OXA-10 Co-ProducingInfection and drug resistance · 2023Article
- Complete genetic characterization of carbapenem-resistantFrontiers in cellular and infection microbiology · 2023Article
- Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance inMicrobial genomics · 2022Article
- Emergence and Evolution of Unique Plasmids HarboringMicrobiology spectrum · 2022Article
- Within patient genetic diversity of blaScientific reports · 2021Article
- Genomic Analysis of two NDM-1 Providencia stuartii Strains Recovered from a Single Patient.Current microbiology · 2020Article
- Isolation and genomic characterization of a pathogenic Providencia rettgeri strain G0519 in turtle Trachemys scripta.Antonie van Leeuwenhoek · 2020Article
- Metallo-β-Lactamases: Structure, Function, Epidemiology, Treatment Options, and the Development Pipeline.Antimicrobial agents and chemotherapy · 2020Review
- In vitro evaluation of double carbapenem and colistin combinations against OXA-48, NDM carbapenemase-producing colistin-resistant Klebsiella pneumoniae strains.Antimicrobial resistance and infection control · 2020Article
- High Rates of New Delhi Metallo-β-Lactamase Carbapenemase Genes in Multi-Drug Resistant Gram-Negative Bacteria in Nicaragua.The American journal of tropical medicine and hygiene · 2020Article
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16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria that produce the broad-spectrum Carbapenem antibiotic New Delhi Metallo-β-lactamase (NDM) place a burden on health care systems worldwide, due to the limited treatment options for infections caused by them and the rapid global spread of this antibiotic resistance mechanism. Although it is believed that the associated resistance gene blaNDM-1 originated in Acinetobacter spp., the role of Enterobacteriaceae in its dissemination remains unclear. In this study, we used whole genome sequencing to investigate the dissemination dynamics of blaNDM-1-positive plasmids in a set of 21 clinical NDM-1-positive isolates from Colombia and Mexico (Providencia rettgeri, Klebsiella pneumoniae, and Acinetobacter baumannii) as well as six representative NDM-1-positive Escherichia coli transconjugants. Additionally, the plasmids from three representative P. rettgeri isolates were sequenced by PacBio sequencing and finished. Our results demonstrate the presence of previously reported plasmids from K. pneumoniae and A. baumannii in different genetic backgrounds and geographically distant locations in Colombia. Three new previously unclassified plasmids were also identified in P. rettgeri from Colombia and Mexico, plus an interesting genetic link between NDM-1-positive P. rettgeri from distant geographic locations (Canada, Mexico, Colombia, and Israel) without any reported epidemiological links was discovered. Finally, we detected a relationship between plasmids present in P. rettgeri and plasmids from A. baumannii and K. pneumoniae. Overall, our findings suggest a Russian doll model for the dissemination of blaNDM-1 in Latin America, with P. rettgeri playing a central role in this process, and reveal new insights into the evolution and dissemination of plasmids carrying such antibiotic resistance genes.
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