Evidence map›Paper›PMID 28854577›Full record

ReviewHuman molecular genetics2017

RNA expression in human retina.

Mingyao Li, Randy J Zauhar, Clare Grazal, Christine A Curcio, Margaret M DeAngelis, Dwight Stambolian

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Human molecular genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. IMI - Myopia Genetics Report.Investigative ophthalmology & visual science · 2019
    Review
  7. RNA Biology in Retinal Development and Disease.Trends in genetics : TIG · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingyao LiDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Randy J ZauharDepartment of Chemistry and Biochemistry, The University of the Sciences in Philadelphia, Philadelphia, PA 19104, USA.
Clare GrazalDepartment of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Christine A CurcioDepartment of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA.
Margaret M DeAngelisDepartment of Ophthalmology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Dwight StambolianDepartment of Ophthalmology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Funding

Genetic Epidemiology of Age-Related Macular Degeneration in the Older Order AmishR01EY023164 · NEI · UNIVERSITY OF PENNSYLVANIA · PI PERICAK-VANCE, MARGARET A., STAMBOLIAN, DWIGHT EDWARD · 2013 to 2017
$6.2M
Statistical Methods for Transcriptome Profiling Using RNA SequencingR01GM108600 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LI, MINGYAO · 2014 to 2017
$1.2M
NEI NIH HHS R01 EY023164NIGMS NIH HHS R01 GM108600
6 · The paper itself

Abstract

Recent Genome-wide Association Studies (GWASs) for eye diseases/traits have delivered a number of novel findings across a diverse range of diseases, including age-related macular degeneration (AMD), glaucoma and refractive error. However, despite this astonishing rate of success, the major challenge still remains to not only confirm that the genes implicated in these studies are truly the genes conferring protection from or risk of disease but also to define the functional roles these genes play in disease. Ongoing evidence is accumulating that the single nucleotide polymorphisms (SNPs) used in GWAS and fine mapping studies have causal effects through their influence on gene expression rather than affecting protein function. The biological interpretation of SNP regulatory effects for a tissue requires knowledge of the transcriptome for that tissue. We summarize the reasons to characterize the complete retinal transcriptome as well as the evidence to include an assessment of differences in regional retinal expression.

Indexed as

Gene Expression RegulationGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGlaucomaHumansMacular DegenerationPhenotypePolymorphism, Single NucleotideRefractive ErrorsRetinaRisk FactorsRNARNA

Identifiers

PMID28854577
PMCPMC5886467

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.