Evidence map›Paper›PMID 28854373›Full record

ArticleCell reports2017

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs.

Chan Zhou, Benoit Molinie, Kaveh Daneshvar, Joshua V Pondick, Jinkai Wang, Nicholas Van Wittenberghe, Yi Xing, Cosmas C Giallourakis, Alan C Mullen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 275 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 1 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 1 synthesis or guideline pooled it, 449 citations in OpenAlex.

  1. Pooled it
  2. NMolecular neurobiology · 2026
    Article
  3. Review
  4. Methylation marks breast cancer metastasis: The roles of mThe Journal of biological chemistry · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Subtype-Specific mInternational journal of molecular sciences · 2026
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Hsa_circ_0101308 adjusted by N6-methyladenosine (mCancer biomarkers : section A of Disease markers · 2025
    Article
  18. Article
  19. Review
  20. Article

215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Chan ZhouGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Benoit MolinieGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Kaveh DaneshvarGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Joshua V PondickGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jinkai WangDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Nicholas Van WittenbergheGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Yi XingDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cosmas C GiallourakisGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: cgiallourakis@mgh.harvard.edu.
Alan C MullenGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: acmullen@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · USUniversity of California, Los Angeles · USHarvard Stem Cell Institute · US

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
VARIATION AND REGULATION OF ALTERNATIVE SPLICING IN HUMAN TRANSCRIPTOMESR01GM088342 · NIGMS · UNIVERSITY OF IOWA · PI XING, YI · 2010 to 2020
$2.9M
NIDDK NIH HHS P30 DK043351NIGMS NIH HHS R01 GM088342
6 · The paper itself

Abstract

N

Indexed as

Genome, HumanAdenosineBase SequenceComputational BiologyDNA Transposable ElementsExonsExoribonucleasesGene Expression RegulationHalf-LifeHeLa CellsHuman Embryonic Stem CellsHumansMethylationMethyltransferasesRNARNA-Binding ProteinsAdenosineDNA Transposable ElementsExoribonucleasesMethyltransferasesMETTL14 protein, humanMETTL3 protein, humanN-methyladenosineribonuclease RRNARNA-Binding ProteinsRNA, CircularRNA, MessengerYTHDF1 protein, humanYTHDF2 protein, humancircular RNAsembryonic stem cellsm6A modificationmethyladenosineMETTL3noncoding RNAsYTHDF2

Identifiers

PMID28854373
PMCPMC5705222
OpenAlexW2752229407

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.