ArticlePLoS neglected tropical diseases2017
Increased rates of Guillain-Barré syndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Clinical manifestations and health outcomes associated with Zika virus infections in adults: A systematic review.PLoS neglected tropical diseases · 2021Pooled it
- Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype.PLoS neglected tropical diseases · 2020Pooled it
- Incidence of Guillain-Barré Syndrome (GBS) in Latin America and the Caribbean before and during the 2015-2016 Zika virus epidemic: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review.F1000Research · 2019Pooled it
- Prevalence of asymptomatic Zika virus infection: a systematic review.Bulletin of the World Health Organization · 2018Pooled it
- Induction of systemic and mucosal immune response against Zika virus by vaccination with non-infectious chimeric VLPs.Scientific reports · 2025Article
- Cluster of Fulminant Guillain-Barre Syndrome in Maharashtra from June to October 2023: Multicentric Survey.Annals of Indian Academy of Neurology · 2025Article
- Article
- Congenital Zika virus infection in laboratory animals: a comparative review highlights translational studies on the maternal-foetal interface.Memorias do Instituto Oswaldo Cruz · 2025Review
- Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024Review
- Interplay Between Zika Virus-Induced Autophagy and Neural Stem Cell Fate Determination.Molecular neurobiology · 2024Article
- Review
- Zika virus tropism and pathogenesis: understanding clinical impacts and transmission dynamics.Virology journal · 2024Review
- Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus.Journal of virology · 2024Article
- Guillain-Barré syndrome: a comprehensive review.European journal of neurology · 2024Review
- Transcriptomic Signatures of Zika Virus Infection in Patients and a Cell Culture Model.Microorganisms · 2024Article
- Activation of ATF3 via the Integrated Stress Response Pathway Regulates Innate Immune Response to Restrict Zika Virus.bioRxiv : the preprint server for biology · 2024Article
- Exploring Iguape Virus-A Lesser-Known Orthoflavivirus.Viruses · 2024Review
- Zika virus infection in a cell culture model reflects the transcriptomic signatures in patients.bioRxiv : the preprint server for biology · 2024Article
- Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mid-2015, Salvador, Brazil, reported an outbreak of Guillain-Barré syndrome (GBS), coinciding with the introduction and spread of Zika virus (ZIKV). We found that GBS incidence during April-July 2015 among those ≥12 years of age was 5.6 cases/100,000 population/year and increased markedly with increasing age to 14.7 among those ≥60 years of age. We conducted interviews with 41 case-patients and 85 neighborhood controls and found no differences in demographics or exposures prior to GBS-symptom onset. A higher proportion of case-patients (83%) compared to controls (21%) reported an antecedent illness (OR 18.1, CI 6.9-47.5), most commonly characterized by rash, headache, fever, and myalgias, within a median of 8 days prior to GBS onset. Our investigation confirmed an outbreak of GBS, particularly in older adults, that was strongly associated with Zika-like illness and geo-temporally associated with ZIKV transmission, suggesting that ZIKV may result in severe neurologic complications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.