Evidence map›Paper›PMID 28854149›Full record

ArticleAging2017

Chronic exercise reduces hypothalamic transforming growth factor-β1 in middle-aged obese mice.

Vagner R R Silva, Carlos K Katashima, Luciene Lenhare, Carla G B Silva, Joseane Morari, Rafael L Camargo, Licio A Velloso, Mario A Saad, Adelino S R da Silva, Jose Rodrigo Pauli and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Vagner R R SilvaSchool of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Carlos K KatashimaDepartment of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
Luciene LenhareSchool of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Carla G B SilvaDepartment of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
Joseane MorariLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 1308-970, Brazil.
Rafael L CamargoDepartment of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
Licio A VellosoLaboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, 1308-970, Brazil.
Mario A SaadDepartment of Internal Medicine, University of Campinas, Campinas, SP, Brazil.
Adelino S R da SilvaPostgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, USP, School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Jose Rodrigo PauliSchool of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Eduardo Rochete RopelleSchool of Applied Sciences, University of Campinas, Limeira, SP, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and aging are associated with hypothalamic inflammation, hyperphagia and abnormalities in the thermogenesis control. It has been demonstrated that the association between aging and obesity induces hypothalamic inflammation and metabolic disorders, at least in part, through the atypical hypothalamic transforming growth factor-β (TGF-β1). Physical exercise has been used to modulate several metabolic parameters. Thus, the aim of this study was to evaluate the impact of chronic exercise on TGF-β1 expression in the hypothalamus of Middle-Aged mice submitted to a one year of high-fat diet (HFD) treatment. We observed that long-term of HFD-feeding induced hypothalamic TGF-β1 accumulation, potentiated the hypothalamic inflammation, body weight gain and defective thermogenesis of Middle-Aged mice when compared to Middle-Aged animals fed on chow diet. As expected, chronic exercise induced negative energy balance, reduced food consumption and increasing the energy expenditure, which promotes body weight loss. Interestingly, exercise training reduced the TGF-β1 expression and IkB-α ser32 phosphorylation in the hypothalamus of Middle-Aged obese mice. Taken together our study demonstrated that chronic exercise suppressed the TGF-β1/IkB-α axis in the hypothalamus and improved the energy homeostasis in an animal model of obesity-associated to aging.

Indexed as

Exercise TherapyAge FactorsAnimalsBody Temperature RegulationDiet, High-FatDisease Models, AnimalDown-RegulationEatingEnergy MetabolismFeeding BehaviorHypothalamusInflammation MediatorsMaleMice, Inbred C57BLNF-KappaB Inhibitor alphaObesityInflammation MediatorsNF-KappaB Inhibitor alphaNfkbia protein, mouseRNA, MessengerTgfb1 protein, mouseTransforming Growth Factor beta1agingexercisehypothalamusobesityTGFβ-1

Identifiers

PMID28854149
PMCPMC5611986
OpenAlexW2752406505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.