Evidence map›Paper›PMID 28854119›Full record

ReviewTranscription2018

New tricks for an old dog: Brf2-dependent RNA Polymerase III transcription in oxidative stress and cancer.

Jerome Gouge, Alessandro Vannini

Open access · hybridAbstract readReview
In one paragraph

Review in Transcription, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs.Antioxidants (Basel, Switzerland) · 2021
    Review
  2. RNA Polymerase III Subunit Mutations in Genetic Diseases.Frontiers in molecular biosciences · 2021
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jerome Gougea The Institute of Cancer Research , London , UK.ORCID 0000-0003-4734-5412
Alessandro Vanninia The Institute of Cancer Research , London , UK.ORCID 0000-0001-7212-5425
Institute of Cancer Research · GB

Funding

Cancer Research UK 21536Wellcome Trust 200818/Z/16/Z
6 · The paper itself

Abstract

Here, we discuss the role of Brf2, an RNA Polymerase III core transcription factor, as a master switch of the oxidative stress response. We highlight the interplay of Brf2 with the Nrf2/Keap1 pathway, as well as the role of Brf2 in cancer and other possible regulations.

Indexed as

Transcription, GeneticHumansNeoplasmsOxidative StressRNA Polymerase IIITranscription Factor TFIIIBBRF2 protein, humanRNA Polymerase IIITranscription Factor TFIIIBBrf2Nrf2redox stressRNA polymerase IIItranscription

Identifiers

PMID28854119
PMCPMC5791813
OpenAlexW2752598659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.