Evidence map›Paper›PMID 28853896›Full record

ArticleNano letters2017

The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles.

Jing Wang, Michael Dzuricky, Ashutosh Chilkoti

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. All-PEG-Like Block Copolymers Self-Assemble into Stealth Nanocarriers for Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jing WangDepartment of Biomedical Engineering, Duke University , Durham, North Carolina 27708, United States.ORCID 0000-0001-8264-4405
Michael DzurickyDepartment of Biomedical Engineering, Duke University , Durham, North Carolina 27708, United States.
Ashutosh ChilkotiDepartment of Biomedical Engineering, Duke University , Durham, North Carolina 27708, United States.
Duke University · US

Funding

Thermally Targeted Drug Delivery by Elastin BiopolymersR01EB000188 · NIBIB · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2002 to 2015
$3.9M
Thermally Triggered Multivalent Targeting of TumorsR01EB007205 · NIBIB · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2007 to 2015
$2.7M
NIBIB NIH HHS R01 EB000188NIBIB NIH HHS R01 EB007205
6 · The paper itself

Abstract

Many promising targeting ligands are hydrophobic peptides, and these ligands often show limited accessibility to receptors, resulting in suboptimal targeting. A systematic study to elucidate the rules for the design of linkers that optimize their presentation on nanoparticles has not been carried out to date. In this study, we recombinantly synthesized an elastin-like polypeptide diblock copolymer (ELP

Indexed as

Drug Delivery SystemsMicellesCell Line, TumorDrug CarriersElastinErb-b2 Receptor Tyrosine KinasesHumansHydrophobic and Hydrophilic InteractionsLigandsNanoparticlesNeoplasmsPeptidesPolymersDrug CarriersElastinERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesLigandsMicellesPeptidesPolymersaffinity targetingelastin-like polypeptideErbB2hydrophobic ligandLinker optimizationnanoparticle

Identifiers

PMID28853896
PMCPMC6372105
OpenAlexW2751425237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.