ArticleThe American journal of gastroenterology2017
Predictors of Early Readmission in Patients With Cirrhosis After the Resolution of Bacterial Infections.
Article in The American journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Interpreting the REACT Score Using the PREDICT Study Framework.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Immune Dysfunction and Infection Risk in Advanced Liver Disease.Gastroenterology · 2025Review
- Low haemoglobin level predicts early hospital readmission in patients with cirrhosis and acute decompensation.JHEP reports : innovation in hepatology · 2023Article
- The mechanistic and prognostic implications of heart rate variability analysis in patients with cirrhosis.Physiological reports · 2022Review
- Changes in the epidemiology and management of bacterial infections in cirrhosis.Clinical and molecular hepatology · 2021Review
- Effects of a reorganization of cirrhosis care during the lockdown for SARS-CoV-2 outbreak.JHEP reports : innovation in hepatology · 2021Article
- Alcohol-related cirrhosis: The most challenging etiology of cirrhosis is more burdensome than ever.Clinical and molecular hepatology · 2021Article
- Acute-on-chronic liver failure: definition, prognosis and management.Frontline gastroenterology · 2020Review
- International normalized ratio and Model for End-stage Liver Disease score predict short-term outcome in cirrhotic patients after the resolution of hepatic encephalopathy.World journal of gastroenterology · 2019Observational
- Outcomes in Patients With Cirrhosis on Primary Compared to Secondary Prophylaxis for Spontaneous Bacterial Peritonitis.The American journal of gastroenterology · 2019Article
- Acute on chronic liver failure in non-alcoholic fatty liver and alcohol associated liver disease.Translational gastroenterology and hepatology · 2019Review
- Hemoglobin A1c Has Suboptimal Performance to Diagnose and Monitor Diabetes Mellitus in Patients with Cirrhosis.Digestive diseases and sciences · 2018Article
- Hepatology in a changing health care landscape: A call for health services research.Hepatology (Baltimore, Md.) · 2018Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn patients with cirrhosis, infections represent a frequent trigger for complications, increasing frequency of hospitalizations and mortality rate. This study aimed to identify predictors of early readmission (30 days) and of mid-term mortality (6 months) in patients with liver cirrhosis discharged after a hospitalization for bacterial and/or fungal infection.
methodsA total of 199 patients with cirrhosis discharged after an admission for a bacterial and/or fungal infection were included in the study and followed up for a least 6 months.
resultsDuring follow-up, 69 patients (35%) were readmitted within 30 days from discharge. C-reactive protein (CRP) value at discharge (odds ratio (OR)=1.91; P=0.022), diagnosis of acute-on-chronic liver failure during the hospital stay (OR=2.48; P=0.008), and the hospitalization in the last 30 days previous to the admission/inclusion in the study (OR=1.50; P=0.042) were found to be independent predictors of readmission. During the 6-month follow-up, 47 patients (23%) died. Age (hazard ratio (HR)=1.05; P=0.001), model of end-stage liver disease (MELD) score (HR=1.13; P<0.001), CRP (HR=1.85; P=0.001), refractory ascites (HR=2.22; P=0.007), and diabetes (HR=2.41; P=0.010) were found to be independent predictors of 6-month mortality. Patients with a CRP >10 mg/l at discharge had a significantly higher probability of being readmitted within 30 days (44% vs. 24%; P=0.007) and a significantly lower probability of 6-month survival (62% vs. 88%; P<0.001) than those with a CRP ≤10 mg/l.
conclusionsCRP showed to be a strong predictor of early hospital readmission and 6-month mortality in patients with cirrhosis after hospitalization for bacterial and/or fungal infection. CRP values could be used both in the stewardship of antibiotic treatment and to identify fragile patients who deserve a strict surveillance program.
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