ArticlePediatric research2017
The triglycerides and glucose index is associated with cardiovascular risk factors in normal-weight children and adolescents.
Article in Pediatric research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Triglyceride-glucose index as a novel predictor of major adverse cardiovascular events in patients with coronary revascularization: a meta-analysis of cohort studies.Annals of medicine · 2026Pooled it
- The effect of exercise intervention on the triglyceride-glucose (TyG) index in adolescents with overweight or obesity: a systematic review and Bayesian dose-response meta-analysis.BMC pediatrics · 2025Pooled it
- Observational
- Association between TyG-BMI and early-onset hypertension: evidence from NHANES.Scientific reports · 2025Article
- Article
- Weight Gain from Birth to Adolescence and TyG Index at Age 18 Years: A Cohort Study in Northeast Brazil.Maternal and child health journal · 2024Article
- The triglyceride-glucose index as an indicator of insulin resistance and cardiometabolic risk in Brazilian adolescents.Archives of endocrinology and metabolism · 2023Article
- Glycemia and associated factors in a pediatric population in Mexico.Frontiers in pediatrics · 2023Article
- Association of three insulin resistance indices with hypertension and body weight among Uyghur adults in rural areas of Xinjiang, China.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- The predictive value of triglyceride-glucose index for in-hospital and one-year mortality in elderly non-diabetic patients with ST-segment elevation myocardial infarction.Journal of geriatric cardiology : JGC · 2022Article
- Metabolic Obesity in People with Normal Body Weight (MONW)-Review of Diagnostic Criteria.International journal of environmental research and public health · 2022Review
- Triglyceride-glucose (TyG) index is a predictor of arterial stiffness, incidence of diabetes, cardiovascular disease, and all-cause and cardiovascular mortality: A longitudinal two-cohort analysis.Frontiers in cardiovascular medicine · 2022Article
- TAG-glucose (TyG) index in childhood: an estimate of cut-off points and the relation to cardiometabolic risk in 4- to 9-year-old children.Public health nutrition · 2021Article
- The triglycerides and glucose index is strongly associated with hepatic steatosis in children with overweight or obesity.European journal of pediatrics · 2021Article
- Insulin Resistance Indexes as Biomarkers of Lifetime Cardiovascular Risk among Adults from Peru.Journal of nutrition and metabolism · 2021Article
- Τriglycerides-glucose (TyG) index is a sensitive marker of insulin resistance in Greek children and adolescents.Endocrine · 2020Article
- The triglycerides and glucose index is associated with cardiovascular risk factors in metabolically obese normal-weight subjects.Journal of endocrinological investigation · 2020Article
- The triglycerides and glucose index is associated with elevated blood pressure in apparently healthy children and adolescents.European journal of pediatrics · 2019Article
- Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease.Journal of thoracic disease · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundGiven the usefulness of the product of triglycerides and glucose (TyG) to recognize individuals at high risk for developing cardiovascular events, the aim of this study was to determine whether the TyG index is associated with the presence of cardiovascular risk factors in apparently healthy normal-weight children and adolescents.MethodsApparently healthy children and adolescents with normal weight, aged 6-15 years, were enrolled in a population-based cross-sectional study. The children were allocated into groups with and without cardiovascular risk factors. Cardiovascular risk factors were considered as the occurrence of at least one of the following: elevated blood pressure, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), or hyperglycemia.ResultsA total of 2,117 children and adolescents were enrolled in the study; of them, 1,078 (50.9%) participants exhibited cardiovascular risk. The adjusted logistic regression analysis showed that elevated TyG index was significantly associated with hypertriglyceridemia (odds ratio (OR)=96.45, 95% confidence interval (CI): 48.44-192.04), low HDL-C (OR=2.07, 95% CI: 1.46-2.92), and hyperglycemia (OR=3.11, 95% CI: 2.05-4.72), but not with elevated blood pressure (OR=1.39, 95% CI: 0.89-2.16).ConclusionThe elevated TyG index is associated with the presence of cardiovascular risk factors in healthy normal-weight children and adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.