ArticleEuropean journal of human genetics : EJHG2017
Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis.
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Article in European journal of human genetics : EJHG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
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14citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 17% of its field
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Global incidence and risk factors for glaucoma: A systematic review and meta-analysis of prospective studies.Journal of global health · 2024Pooled it
- Background polygenic risk modulates the association between glaucoma and cardiopulmonary diseases and measures: an analysis from the UK Biobank.The British journal of ophthalmology · 2023Pooled it
- High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.Investigative ophthalmology & visual science · 2022Pooled it
- Genomic structural equation Modeling analysis of glaucoma Endophenotypes: investigating genetic architecture and non-intraocular pressure mechanisms.Human molecular genetics · 2025Article
- Optimizing the sequential approach of combined phacoemulsification and gonioscopy-assisted transluminal trabeculotomy (GATT) in primary open-angle glaucoma.BMC ophthalmology · 2025Article
- GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma.Nature communications · 2024Article
- Appraising the Effects of Metabolic Traits on the Risk of Glaucoma: A Mendelian Randomization Study.Metabolites · 2023Article
- 10 Years of GWAS in intraocular pressure.Frontiers in genetics · 2023Review
- From the past to the present, optical coherence tomography in glaucoma: a practical guide to a common disease.F1000Research · 2023Review
- Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma.Nature communications · 2022Article
- Review
- Objectives, design and main findings until 2020 from the Rotterdam Study.European journal of epidemiology · 2020Article
- Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.American journal of ophthalmology · 2019Article
- Polygenic Risk Score Is Associated With Intraocular Pressure and Improves Glaucoma Prediction in the UK Biobank Cohort.Translational vision science & technology · 2019Article
Corrections and comments
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Authors and funding
46 authors at 20 institutions in 4 countries.
Hugues AschardDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, MA, USA.
Jae H KangChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4812-0557
Adriana I IglesiasDepartment of Epidemiology, Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands.
Pirro HysiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Jessica N Cooke BaileyDepartment of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Anthony P KhawajaDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
R Rand AllinghamDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Allison Ashley-KochDepartment of Medicine, Duke University Medical Center, Durham, NC, USA.
Richard K LeeBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Sayoko E MoroiDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
Murray H BrilliantCenter for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.
Gadi WollsteinDepartment of Ophthalmology, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA.
Joel S SchumanDepartment of Ophthalmology, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA.
John H FingertDepartments of Ophthalmology and Anatomy/Cell Biology, University of Iowa, College of Medicine, Iowa City, IO, USA.
Donald L BudenzDepartment of Ophthalmology, University of North Carolina, Chapel Hill, NC, USA.
Tony RealiniDepartment of Ophthalmology, WVU Eye Institute, Morgantown, WV, USA.
Terry GaasterlandScripps Genome Center, University of California at San Diego, San Diego, CA, USA.
William K ScottInstitute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Kuldev SinghDepartment of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Arthur J SitDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.
Robert P IgoDepartment of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Yeunjoo E SongDepartment of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Lisa HarkWills Eye Hospital, Glaucoma Research Center, Philadelphia, PA, USA.
Robert RitchEinhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.ORCID 0000-0002-9368-7547
Douglas J RheeDepartment of Ophthalmology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Vikas GulatiDepartment of Ophthalmology &Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
Shane HavenDepartment of Ophthalmology &Visual Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
Douglas VollrathDepartment of Genetics, Stanford University, Palo Alto, CA, USA.
Donald J ZackWilmer Eye Institute, Johns Hopkins University Hospital, Baltimore, MD, USA.
Felipe MedeirosDepartment of Ophthalmology, Hamilton Eye Center, University of California at San Diego, San Diego, CA, USA.
Robert N WeinrebDepartment of Ophthalmology, Hamilton Eye Center, University of California at San Diego, San Diego, CA, USA.
Ching-Yu ChengSingapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
William G ChristenDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Margaret A Pericak-VanceInstitute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Yutao LiuDepartment of Cellular Biology &Anatomy, Augusta University, Augusta, GA, USA.
Peter KraftDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, MA, USA.
Julia E RichardsDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
Bernard A RosnerDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, MA, USA.
Michael A HauserDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
International Glaucoma Genetics Consortium
Caroline C W KlaverDepartment of Epidemiology, Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands.
Cornelia M vanDuijnDepartment of Epidemiology, Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands.
Jonathan HainesDepartment of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Janey L WiggsDepartment of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.
Louis R PasqualeChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USUniversity School · USDuke Medical Center · USErasmus MC · NLUniversity of Miami · USHarvard University · USNebraska Medical Center · USNYU Langone Health · USStanford University · USUniversity of Michigan · USUniversity of San Diego · USAugusta University · USJohns Hopkins University · USKing's College London · GBMarshfield Clinic · USMassachusetts Eye and Ear Infirmary · USMayo Clinic in Arizona · USNational University of Singapore · SGNew York Eye and Ear Infirmary · USScripps Institution of Oceanography · US
Funding
P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1MGene-Environment Interactions in GlaucomaR01EY015473 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI PASQUALE, LOUIS ROBERT · 2005 to 2021
$8.3MThe NEIGHBORHOOD: POAG Heritable Overall Operational DatabaseR01EY022305 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI WIGGS, JANEY L · 2012 to 2025
$7.9MSOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0MMolecular Genetics of Norma Tension GlaucomaR01EY023512 · NEI · UNIVERSITY OF IOWA · PI FINGERT, JOHN H, MULLINS, ROBERT FOSTER · 2014 to 2017
$1.8MGenes and Environment Initiative in GlaucomaU01HG004728 · NHGRI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI PASQUALE, LOUIS ROBERT · 2008 to 2009
$1.0MData commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598kNEI NIH HHS P30 EY014104NEI NIH HHS R01 EY015473NEI NIH HHS R01 EY022305NEI NIH HHS R01 EY023512NHGRI NIH HHS U01 HG004728NIH HHS S10 OD018164
Abstract
Primary open-angle glaucoma (POAG) is the most common chronic optic neuropathy worldwide. Epidemiological studies show a robust positive relation between intraocular pressure (IOP) and POAG and modest positive association between IOP and blood pressure (BP), while the relation between BP and POAG is controversial. The International Glaucoma Genetics Consortium (n=27 558), the International Consortium on Blood Pressure (n=69 395), and the National Eye Institute Glaucoma Human Genetics Collaboration Heritable Overall Operational Database (n=37 333), represent genome-wide data sets for IOP, BP traits and POAG, respectively. We formed genome-wide significant variant panels for IOP and diastolic BP and found a strong relation with POAG (odds ratio and 95% confidence interval: 1.18 (1.14-1.21), P=1.8 × 10
Indexed as
Linkage DisequilibriumBlood PressureFemaleGenetic Predisposition to DiseaseGlaucoma, Open-AngleHumansIntraocular PressureMale
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.