ArticleeLife2017
Evolutionary routes to biochemical innovation revealed by integrative analysis of a plant-defense related specialized metabolic pathway.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
62 citing papers in PubMed, 120 citations in OpenAlex.
- Structurally diverse acylsugars on wild tomatillo fruit surfaces.Horticulture research · 2026Article
- Review
- The plasma membrane ABC transporter Sl-ABCB5 mediates acylsugar secretion from tomato trichomes to confer insect resistance.Plant communications · 2026Article
- Functional diversification of WRINKLED3 integrates fatty acid metabolism with insecticidal acylsugar production in Solanaceae species.Nature communications · 2026Article
- Structural innovation in the evolution of plant chemical defense.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Resin Glycosides fromJournal of natural products · 2026Article
- Article
- Exploring leaf anatomy in Athenaea species (Solanaceae Juss.): studying secondary metabolite diversity and potential taxonomic characters.Protoplasma · 2025Article
- Metabolomics navigates natural variation in pathogen-induced secondary metabolism across soybean cultivar populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Role of LEAFLESS, an AP2/ERF family transcription factor, in the regulation of trichome specialized metabolism.The New phytologist · 2025Article
- Extraction, Annotation, and Purification of Resin Glycosides from the Morning Glory Family (Convolvulaceae).Methods in molecular biology (Clifton, N.J.) · 2025Article
- Sticky plants and plant-based glues: potential for pest control.Frontiers in plant science · 2025Review
- Identification and Structural Elucidation of Acylsugars in Tomato Leaves Using Liquid Chromatography-Ion Mobility-Tandem Mass Spectrometry (LC-IM-MS/MS).Journal of the American Society for Mass Spectrometry · 2025Article
- MgJACS Au · 2024Article
- Evolution of plant metabolism: the state-of-the-art.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Different multicellular trichome types coordinate herbivore mechanosensing and defense in tomato.The Plant cell · 2024Article
- Trading acyls and swapping sugars: metabolic innovations in Solanum trichomes.Plant physiology · 2024Article
- ΔiScience · 2024Article
- Tomato root specialized metabolites evolved through gene duplication and regulatory divergence within a biosynthetic gene cluster.Science advances · 2024Article
- Estimating Transcriptome Diversity and Specialization inPlants (Basel, Switzerland) · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The diversity of life on Earth is a result of continual innovations in molecular networks influencing morphology and physiology. Plant specialized metabolism produces hundreds of thousands of compounds, offering striking examples of these innovations. To understand how this novelty is generated, we investigated the evolution of the Solanaceae family-specific, trichome-localized acylsugar biosynthetic pathway using a combination of mass spectrometry, RNA-seq, enzyme assays, RNAi and phylogenomics in different non-model species. Our results reveal hundreds of acylsugars produced across the Solanaceae family and even within a single plant, built on simple sugar cores. The relatively short biosynthetic pathway experienced repeated cycles of innovation over the last 100 million years that include gene duplication and divergence, gene loss, evolution of substrate preference and promiscuity. This study provides mechanistic insights into the emergence of plant chemical novelty, and offers a template for investigating the ~300,000 non-model plant species that remain underexplored.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.