Evidence map›Paper›PMID 28853330›Full record

ArticleRedox report : communications in free radical research2018

Activity of the antioxidant enzyme paraoxonase in Argentinean children living at high altitude.

V Hirschler, M Martín, K Oestreicher, C Molinari, W Tetzlaff, E Botta, L Boero, F Brites, San Antonio de los Cobres Study Group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox report : communications in free radical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

V Hirschlera University of Buenos Aires , Buenos Aires , Argentina.
M Martínb Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry , University of Buenos Aires-CONICET , Buenos Aires , Argentina.
K Oestreichera University of Buenos Aires , Buenos Aires , Argentina.
C Molinaria University of Buenos Aires , Buenos Aires , Argentina.
W Tetzlaffb Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry , University of Buenos Aires-CONICET , Buenos Aires , Argentina.
E Bottab Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry , University of Buenos Aires-CONICET , Buenos Aires , Argentina.
L Boerob Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry , University of Buenos Aires-CONICET , Buenos Aires , Argentina.
F Britesb Laboratory of Lipids and Atherosclerosis, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry , University of Buenos Aires-CONICET , Buenos Aires , Argentina.
San Antonio de los Cobres Study Group
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Buenos Aires · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildren living at high altitude in San Antonio de los Cobres (SAC), Argentina, were shown to have lower high-density lipoprotein cholesterol (HDL-C) levels than Buenos Aires (BA) children. HDL antioxidant capacity is mainly attributed to paraoxonase1 (PON1).

objectiveTo compare PON1 activity in indigenous SAC vs. BA children.

methodsA cross-sectional study compared 158 SAC vs. 97 BA children (6-16 years). Anthropometric data and lipoprotein profile were measured. PON1 was evaluated employing paraoxon (PON) and phenylacetate (ARE) activity.

resultsThe prevalence of overweight/obesity was lower in SAC than in BA children (18.3 vs. 30.9%). Triglycerides (1.34 vs. 0.90 mmol/l), apo B (0.84 vs.0.72 g/l), apo A-I (1.33 vs. 1.27 g/l), and ARE activity (100 vs. 90 µmol/ml/min) were higher, while HDL-C (1.16 vs. 1.32 mmol/l) and PON activity (170 vs. 203 nmol/ml/min) were lower in SAC than in BA. Separate multiple linear regression analyses showed that SAC children had significantly higher triglyceride (Beta -0.38), apo B (Beta -0.34), and ARE (Beta -0.36) plus lower HDL-C (Beta 0.33) and PON (Beta 0.25) compared with BA; adjusted for age, gender, and BMI.

conclusionSAC showed an unfavorable lipoprotein profile, lower PON and higher ARE activities compared with BA children, suggesting the presence of altered HDL metabolism and antioxidant capacity.

Indexed as

AdolescentAltitudeApolipoprotein A-IArgentinaAryldialkylphosphataseChildCholesterol, HDLCross-Sectional StudiesFemaleHumansLinear ModelsLipidsMalePediatric ObesityPhenylacetatesRisk FactorsApolipoprotein A-IAryldialkylphosphataseCholesterol, HDLLipidsPhenylacetatesphenylacetic acidPON1 protein, humanTriglyceridesatherosclerosisHDLHigh altitudeindigenous school childrenPON1

Identifiers

PMID28853330
PMCPMC6748698
OpenAlexW2753248195

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.