ReviewJournal of endocrinological investigation2018
Thyroid diseases and bone health.
Review in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 123 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Final Height in Patients With Congenital Hypothyroidism Diagnosed by Neonatal Screening
Early Life Determinants of Skeletal Maturation and Endocrine Health in Young Adults - A Nationwide Birth Cohort Study
Who cites it
123 citing papers in PubMed, 3 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Multiple thyroid disorders and risk of osteoporosis: a two-sample Mendelian randomization study.Journal of bone and mineral metabolism · 2025Pooled it
- Effects of levothyroxine therapy on bone and mineral metabolism in hypothyroidism: a systematic review and meta-analysis.BMC endocrine disorders · 2025Pooled it
- Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.Thyroid : official journal of the American Thyroid Association · 2021Guideline
- A Clinically Aligned Two-Stage Machine Learning Framework for Predicting Hungry Bone Syndrome After Parathyroidectomy.Endocrinology, diabetes & metabolism · 2026Article
- Signalling Pathways and Mechanical Forces Interact in Craniofacial Development and Homeostasis.International dental journal · 2026Review
- Association Between Hypothyroidism and Postoperative Complications Following Operative Ankle Fracture Fixation: A Retrospective Cohort Study.Foot & ankle orthopaedics · 2026Article
- Review
- Gestational exposure to organophosphate ester flame retardants and child growth in weight, height, and body mass index at age 2-10 years: the Environmental influences on Child Health Outcomes Program.Environmental research · 2026Article
- Osteometabolic complications in patients with secreting pituitary adenomas: Is there an impact of gender?Pituitary · 2026Review
- Osteoporosis independent of traditional risk factors in hyperthyroid patients in a resource-limited setting: An observational study.Medicine · 2026Observational
- Ultrasonographic Evaluation of Pediatric Thyroid Nodules: Adult Risk Stratification Systems, 2021 K-TIRADS Revision, and Future Refinements.Korean journal of radiology · 2026Review
- Thyroid disorders in idiopathic inflammatory myopathies: prevalence and related clinical scenarios.BMC endocrine disorders · 2026Article
- The effect of replacement versus suppressive doses of levothyroxine on bone mineral density.BMC endocrine disorders · 2026Article
- Current status of hypothyroidism control in Guangzhou area, China: a cross-sectional survey.BMC endocrine disorders · 2026Article
- Maternal serum polybrominated diphenyl ether concentrations during pregnancy and adolescent bone mineral density at age 12 years.International journal of hygiene and environmental health · 2026Article
- Bone microarchitecture assessed by HR-pQCT in syndrome of inappropriate secretion of thyrotropin with thyrotoxicosis.Archives of osteoporosis · 2026Article
- Advances in the management of osteopenia: a case series.Journal of medical case reports · 2026Article
- Association of Polypharmacy and Bone Mineral Density: A Cross-Sectional Analysis of Geriatric Inpatients in Germany.Journal of clinical medicine · 2026Article
- Cross-sectional association of arsenic exposure with thyroid function in Bangladeshi children aged 5 to 7 years.Environmental health : a global access science source · 2026Article
- Lack of difference in thyroid hormone profile between offspring conceived naturally and through ART.Human reproduction open · 2026Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Thyroid hormones are essential for skeletal development and are important regulators of bone maintenance in adults. Childhood hypothyroidism causes delayed skeletal development, retarded linear growth and impaired bone mineral accrual. Epiphyseal dysgenesis is evidenced by classic features of stippled epiphyses on X-ray. In severe cases, post-natal growth arrest results in a complex skeletal dysplasia. Thyroid hormone replacement stimulates catch-up growth and bone maturation, but recovery may be incomplete dependent on the duration and severity of hypothyroidism prior to treatment. A severe phenotype characteristic of hypothyroidism occurs in children with resistance to thyroid hormone due to mutations affecting THRA encoding thyroid hormone receptor α (TRα). Discovery of this rare condition recapitulated animal studies demonstrating that TRα mediates thyroid hormone action in the skeleton. In adults, thyrotoxicosis is well known to cause severe osteoporosis and fracture, but cases are rare because of prompt diagnosis and treatment. Recent data, however, indicate that subclinical hyperthyroidism is associated with low bone mineral density (BMD) and an increased risk of fracture. Population studies have also shown that variation in thyroid status within the reference range in post-menopausal women is associated with altered BMD and fracture risk. Thus, thyroid status at the upper end of the euthyroid reference range is associated with low BMD and increased risk of osteoporotic fragility fracture. Overall, extensive data demonstrate that euthyroid status is required for normal post-natal growth and bone mineral accrual, and is fundamental for maintenance of adult bone structure and strength.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.