ArticleThe Histochemical journal1987
Immunoelectron microscopic localization of D-amino acid oxidase in rat kidney and liver.
Article in The Histochemical journal, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Variability in intracellular localization of D-amino acid oxidase in choroid plexus epithelial cells.The FEBS journal · 2026Article
- Mammals sustain amino acid homochirality against chiral conversion by symbiotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- D-Serine: A Cross Species Review of Safety.Frontiers in psychiatry · 2021Review
- d-amino Acids in Health and Disease: A Focus on Cancer.Nutrients · 2019Review
- Mouse d-Amino-Acid Oxidase: Distribution and Physiological Substrates.Frontiers in molecular biosciences · 2017Review
- Production of hydrogen sulfide from d-cysteine and its therapeutic potential.Frontiers in endocrinology · 2013Article
- A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells.Nature communications · 2013Article
- The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.Molecular psychiatry · 2010Review
- In situ heterogeneity of peroxisomal oxidase activities: an update.The Histochemical journal · 1996Review
- Localization of D-amino acid oxidase mRNA in the mouse kidney and the effect of testosterone treatment.Histochemistry and cell biology · 1995Article
- Immunogold localization of peroxisomal enzymes in Epon-embedded liver tissue. Enhancement of sensitivity by etching with ethanolic sodium hydroxide.Histochemistry · 1988Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intracellular localization of D-amino acid oxidase in rat kidney and liver has been investigated using the indirect immunogold postembedding technique. Different fixation and embedding conditions for optimal preservation of antigenicity and fine structure have been tested. Immunolabelling was possible only in tissues embedded in polar resins (glycol methacrylate and Lowicryl K4M). In kidney the enzyme was demonstrable only in the peroxisomes of the proximal tubule, where it was associated with the peroxisome core. The enzyme was present in all the peroxisomes of the proximal tubule and appeared to be codistributed with catalase. Control experiments and quantitative analysis confirmed the specificity of the D-amino acid oxidase immunolocalization. All the other cells in kidney failed to demonstrate any labelling. In liver, the immunolabelling was present in the matrix of the hepatocyte peroxisomes, whereas no traces of the enzyme were found in the nucleoid. The intensity of the immunolabelling in liver peroxisomes was lower than in kidney. No specific labelling was observed in cells other than hepatocytes.
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