Evidence map›Paper›PMID 28852913›Full record

ArticleFamilial cancer2018

Cancer patients' intentions towards receiving unsolicited genetic information obtained using next-generation sequencing.

Rhodé M Bijlsma, Hester Wessels, Roel H P Wouters, Anne M May, Margreet G E M Ausems, Emile E Voest, Annelien L Bredenoord

Abstract read
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In one paragraph

Article in Familial cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rhodé M BijlsmaDepartment of Medical Oncology, Cancer Center, University Medical Center Utrecht, Q05.4.300, PO Box 85500, 3508 GA, Utrecht, The Netherlands. r.m.bijlsma@umcutrecht.nl.ORCID 0000-0003-0980-6652
Hester WesselsDepartment of Corporate Communications, University Medical Center Utrecht, Utrecht, The Netherlands.
Roel H P WoutersDepartment of Medical Humanities, Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Margreet G E M AusemsDepartment of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
Emile E VoestDepartment of Medical Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
Annelien L BredenoordDepartment of Medical Humanities, Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands.

Funding

KWF Kankerbestrijding grant UU2014-7469
6 · The paper itself

Abstract

Next-generation sequencing (NGS) can be used to generate information about a patient's tumour and personal genome. This powerful diagnostic tool provides solicited and unsolicited hereditary genetic (risk) information that could have consequences for cancer patients and their quality of life. A well-defined approach for returning appropriate genetic risk information is needed in personalized cancer care. A qualitative design with semi-structured interviews was used. We conducted interviews with 24 Dutch patients with different types of cancer, both NGS-experienced and NGS-inexperienced, to learn their intentions, needs and preferences towards receiving unsolicited genetic information obtained using NGS. Almost all participants had a positive attitude towards receiving unsolicited findings. After receiving comprehensive background information on NGS, including a binning model of four categories of unsolicited findings, most participants preferred to receive only subsets of genetic information. Their main concern was their own and others' (including family members) ability to cope with (the increased risk of having) a genetic disorder. Providing background information gave cancer patients the opportunity to select subsets of findings and increased their ability to make an informed choice. Special attention is needed for social and emotional factors to support the patients themselves and when communicating test results with their family members.

Indexed as

Decision MakingGenetic TestingPrecision MedicineAdaptation, PsychologicalAdultAgedFamilyFemaleHigh-Throughput Nucleotide SequencingHumansIntentionMaleMiddle AgedNeoplastic Syndromes, HereditaryNetherlandsPatient PreferenceCancer patients’ intentionsEthicsGeneticsIncidental findingNeeds and preferencesNext-generation DNA sequencingTheory of planned behaviourUnsolicited finding

Identifiers

PMID28852913
PMCPMC5893692

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.