Evidence map›Paper›PMID 28852814›Full record

ArticleThe Journal of membrane biology2017

Identification of Resveratrol, an Herbal Compound, as an Activator of the Calcium-Activated Chloride Channel, TMEM16A.

Ran Chai, Yafei Chen, Hongbo Yuan, Xuzhao Wang, Shuai Guo, Jinlong Qi, Hailin Zhang, Yong Zhan, Hailong An

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of membrane biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Inhibition of ANO1 byInternational journal of molecular sciences · 2023
    Article
  5. Review
  6. Article
  7. The CaActa pharmaceutica Sinica. B · 2021
    Review
  8. Review
  9. Review
  10. Review
  11. Potential Adverse Effects of Resveratrol: A Literature Review.International journal of molecular sciences · 2020
    Review
  12. Article
  13. Recent progress in structural studies on TMEM16A channel.Computational and structural biotechnology journal · 2020
    Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ran ChaiSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, China.
Yafei ChenKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.
Hongbo YuanSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, China.
Xuzhao WangKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.
Shuai GuoKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China.
Jinlong QiKey Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Pharmacology and Toxicology for New Drug, Hebei Province, Department of Pharmacology, Hebei Medical University, Shijiazhuang, 050017, China.
Hailin ZhangKey Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of Pharmacology and Toxicology for New Drug, Hebei Province, Department of Pharmacology, Hebei Medical University, Shijiazhuang, 050017, China.
Yong ZhanSchool of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, China. zhany@hebut.edu.cn.
Hailong AnKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, China. hailong_an@hebut.edu.cn.ORCID http://orcid.org/0000-0001-7947-357X
Hebei University of Technology · CNHebei Medical University · CN

Funding

The Fund for Outstanding Talents of Hebei Province of China C201400305The National Natural Science Fund of China 11247010The National Natural Science Fund of China 11475053The National Natural Science Fund of China 31400711The Natural Science Fund for Distinguished Young Scholars of the Hebei Province of China C2015202340
6 · The paper itself

Abstract

Calcium-activated chloride channels (CaCCs) play vital roles in a variety of physiological processes. Dysfunction of the CaCCs is implicated in many diseases. Drug discovery targeting at CaCCs has recently become possible with the determination that TMEM16A is the molecular identity of CaCCs. In this study, we demonstrated that resveratrol (RES), a Chinese traditional medicine compound, is a novel activator of TMEM16A. The yellow fluorescence protein quenching assay and measurement of intracellular calcium fluorescence intensity show that RES activates TMEM16A channels in an intracellular Ca

Indexed as

AnimalsAnoctamin-1Calcium SignalingChloride Channel AgonistsDose-Response Relationship, DrugDrugs, Chinese HerbalGastrointestinal MotilityGuinea PigsHEK293 CellsHumansIleumNeoplasm ProteinsPlants, MedicinalResveratrolStilbenesANO1 protein, humanAnoctamin-1Chloride Channel AgonistsDrugs, Chinese HerbalNeoplasm ProteinsResveratrolStilbenesActivatorDrug discoveryGastrointestinal hypomotilityResveratrolTMEM16A

Identifiers

PMID28852814
OpenAlexW2752019958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.