ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2017
An ultra-dense integrated linkage map for hexaploid chrysanthemum enables multi-allelic QTL analysis.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 65 citations in OpenAlex.
- Multi-locus GWAS uncovers favorable alleles and candidate genes underlying water stress response in chrysanthemum.BMC plant biology · 2026Article
- QTL detection and candidate gene identification for prostrate growth habit in interspecific crosses of wild chrysanthemum (Horticulture research · 2025Article
- Major Gene with Polygene Inheritance Analysis of Prostrate Growth Habit in Hybrids ofPlants (Basel, Switzerland) · 2025Article
- Rhamnosyltransferases involved in the biosynthesis of flavone rutinosides in Chrysanthemum species.Plant physiology · 2022Article
- Towards the Improvement of Ornamental Attributes in Chrysanthemum: Recent Progress in Biotechnological Advances.International journal of molecular sciences · 2022Review
- De novo whole-genome assembly of Chrysanthemum makinoi, a key wild chrysanthemum.G3 (Bethesda, Md.) · 2022Article
- First genetic maps development and QTL mining inFrontiers in plant science · 2022Article
- A genome-wide association and fine-mapping study of white rust resistance in hexaploid chrysanthemum cultivars with a wild diploid reference genome.Horticulture research · 2022Article
- Detecting quantitative trait loci and exploring chromosomal pairing in autopolyploids using polyqtlR.Bioinformatics (Oxford, England) · 2021Article
- A chromosome-level genome sequence of Chrysanthemum seticuspe, a model species for hexaploid cultivated chrysanthemum.Communications biology · 2021Article
- Review
- DNA marker for resistance toBreeding science · 2021Article
- Article
- QTL Mapping for Resistance to Cankers Induced byPathogens (Basel, Switzerland) · 2020Article
- Linkage Map Development by EST-SSR Markers and QTL Analysis for Inflorescence and Leaf Traits in Chrysanthemum (Plants (Basel, Switzerland) · 2020Article
- Anthocyanins in Floral Colors: Biosynthesis and Regulation in Chrysanthemum Flowers.International journal of molecular sciences · 2020Review
- Multiple QTL Mapping in Autopolyploids: A Random-Effect Model Approach with Application in a Hexaploid Sweetpotato Full-Sib Population.Genetics · 2020Article
- Unraveling the Hexaploid Sweetpotato Inheritance Using Ultra-Dense Multilocus Mapping.G3 (Bethesda, Md.) · 2020Article
- High-density genetic map construction and identification of loci controlling flower-type traits in Chrysanthemum (Horticulture research · 2020Article
- Linkage Analysis and Haplotype Phasing in Experimental Autopolyploid Populations with High Ploidy Level Using Hidden Markov Models.G3 (Bethesda, Md.) · 2019Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageWe constructed the first integrated genetic linkage map in a polysomic hexaploid. This enabled us to estimate inheritance of parental haplotypes in the offspring and detect multi-allelic QTL. Construction and use of linkage maps are challenging in hexaploids with polysomic inheritance. Full map integration requires calculations of recombination frequency between markers with complex segregation types. In addition, detection of QTL in hexaploids requires information on all six alleles at one locus for each individual. We describe a method that we used to construct a fully integrated linkage map for chrysanthemum (Chrysanthemum × morifolium, 2n = 6x = 54). A bi-parental F1 population of 406 individuals was genotyped with an 183,000 SNP genotyping array. The resulting linkage map consisted of 30,312 segregating SNP markers of all possible marker dosage types, representing nine chromosomal linkage groups and 107 out of 108 expected homologues. Synteny with lettuce (Lactuca sativa) showed local colinearity. Overall, it was high enough to number the chrysanthemum chromosomal linkage groups according to those in lettuce. We used the integrated and phased linkage map to reconstruct inheritance of parental haplotypes in the F1 population. Estimated probabilities for the parental haplotypes were used for multi-allelic QTL analyses on four traits with different underlying genetic architectures. This resulted in the identification of major QTL that were affected by multiple alleles having a differential effect on the phenotype. The presented linkage map sets a standard for future genetic mapping analyses in chrysanthemum and closely related species. Moreover, the described methods are a major step forward for linkage mapping and QTL analysis in hexaploids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.