ArticleAnalytical and bioanalytical chemistry2017
Ultrasensitive SERS immunoassay based on diatom biosilica for detection of interleukins in blood plasma.
Article in Analytical and bioanalytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 71 citations in OpenAlex.
- Multiplexed Detection of Cancer Protein Biomarkers via Surface-Enhanced Raman Scattering Immunoassays on Natural Diatomite Strips.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Gold- or Silver-Nanoparticle SERS Platforms for Plasma-Based Diagnostics and AI-Driven Analysis.Sensors (Basel, Switzerland) · 2026Review
- Detecting Attomolar Concentrations of Interleukin IL-17A via Pollen-Based Nanoplasmonic Biochips.Biosensors · 2025Article
- Diatoms: harnessing nature's microscopic marvels for biosensing and multifaceted applications.Biophysical reviews · 2025Review
- Synthesis and Antimicrobial Activity of 3D Micro-Nanostructured Diatom Biosilica Coated by Epitaxially Growing Ag-AgCl Hybrid Nanoparticles.Biomimetics (Basel, Switzerland) · 2023Article
- Article
- Aluminum Foil vs. Gold Film: Cost-Effective Substrate in Sandwich SERS Immunoassays of Biomarkers Reveals Potential for Selectivity Improvement.International journal of molecular sciences · 2023Article
- Photonic Nano-/Microstructured Diatom Based Biosilica in Metal Modification and Removal-A Review.Materials (Basel, Switzerland) · 2022Review
- Novel Drug and Gene Delivery System and Imaging Agent Based on Marine Diatom Biosilica Nanoparticles.Marine drugs · 2022Review
- Diatom biosilica in plasmonics: applications in sensing, diagnostics and therapeutics [Invited].Biomedical optics express · 2022Review
- Separation and detection of E. coli O157:H7 using a SERS-based microfluidic immunosensor.Mikrochimica acta · 2022Article
- Article
- Cytokines: From Clinical Significance to Quantification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Microbial Nanotechnology: Challenges and Prospects for Green Biocatalytic Synthesis of Nanoscale Materials for Sensoristic and Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2019Review
- Recent Advances on Diatom-Based Biosensors.Sensors (Basel, Switzerland) · 2019Review
- Photovoltaic cells as a highly efficient system for biomedical and electrochemical surface-enhanced Raman spectroscopy analysis.RSC advances · 2019Article
- Analysis of Biomolecules Based on the Surface Enhanced Raman Spectroscopy.Nanomaterials (Basel, Switzerland) · 2018Review
- Application of Vibrational Spectroscopy and Imaging to Point-of-Care Medicine: A Review.Applied spectroscopy · 2018Review
- Steel Wire Mesh as a Thermally Resistant SERS Substrate.Nanomaterials (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An ultrasensitive surface-enhanced Raman scattering (SERS) immunoassay based on diatom biosilica with integrated gold nanoparticles (AuNPs) for the detection of interleukin 8 (IL-8) in blood plasma has been developed. The SERS sensing originates from unique features of the diatom frustules, which are capable of enhancing the localized surface-plasmon resonance of metal nanostructures. The SERS immune tags ware fabricated by functionalizing 70-nm Au nanoparticles with DTNB (i.e., 5,5'-dithiobis(2-nitrobenzoic acid)), which acted as a Raman reporter molecule, as well as the specific antibodies. These DTNB-labeled immune-AuNPs can form a sandwich structure with IL-8 antigens (infection marker) and the antibodies immobilized on the biosilica material. Our method showed an improved IL-8 detection limit in comparison to standard ELISA methods. The current detection limit for IL-8 using a conventional ELISA test is about 15.6 pg mL
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.