Evidence map›Paper›PMID 28852730›Full record

ArticleAfrican journal of traditional, complementary, and alternative medicines : AJTCAM2016

DIFFERENT CONCENTRATIONS OF SIJUNZI DECOCTION INHIBIT PROLIFERATION AND INDUCE APOPTOSIS OF HUMAN GASTRIC CANCER SGC-7901 SIDE POPULATION.

Jun Qian, Jing Li, Jianguang Jia, Xin Jin, Dajun Yu, Chenxu Guo, Bo Xie, Liyu Qian

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In one paragraph

Article in African journal of traditional, complementary, and alternative medicines : AJTCAM, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Antitumor Effect of Si-Jun-Zi Decoction on SGC7901 Gastric Cancer Cells by CMTM2 Activation.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. [Anti-tumor and immune-modulating effect ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jun QianThird Department of Tumor Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, PR China.
Jing LiThird Department of Tumor Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, PR China.
Jianguang JiaThird Department of Tumor Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, PR China.
Xin JinThird Department of Tumor Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, PR China.
Dajun YuThird Department of Tumor Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, PR China.
Chenxu GuoThird Department of Tumor Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, PR China.
Bo XieThird Department of Tumor Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, PR China.
Liyu QianThird Department of Tumor Surgery, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSijunzi Decoction (SD) is a traditional Chinese medicine which is composed of Ginseng, Atractylodes, Poria and Licorice. It is one of the commonly used Chinese traditional medicines that showed anti-gastric cancer activity in clinical studies. Previous evidence demonstrated SD parties (Ginseng, Atractylodes, Poria, Licorice) can inhibit proliferation and induced apoptosis for gastric cancer cell. In order to further investigate the anticancer effect of SD in gastric cancer, we observed the effects of different concentrations of SD on proliferation and apoptosis of Side Population Cells (SP) of human gastric cancer SGC-7901. MATERIALS AND

methodsSGC-7901 SP and Non- Side Population Cells (NSP) were sorted through flow cytometry; to detect the changes of proliferation of SP and NSP before and after the intervention of serum containing different concentrations of SD using cck-8 method; to detect the changes of cell cycle and apoptosis of SP and NSP before and after the intervention of serum containing different concentrations of SD through flow cytometry; to detect the effects of serum containing different concentrations of SD on apoptosis-related proteins Bax and Bcl-2 of SP and NSP before and after the intervention by western-blot.

resultsIt was found that different concentrations of SD serum treatments inhibited cell proliferation in a time-dependent and concentration-dependent manner. Compared with the control group (normal saline serum treatment), there were increase in G1/G0 phase population of SP and NSP, and decrease in G2/M and S phase population (

conclusionWith the increase of SD serum concentrations, SD can gradually inhibits the proliferation of SP of SGC-7901 cell lines through G1/G0 phase arrest and followed by apoptosis which involves the up-regulation of Bax and the down-regulation of Bcl-2.

Indexed as

Antineoplastic AgentsApoptosisbcl-2-Associated X ProteinCell CycleCell Line, TumorCell ProliferationDown-RegulationDrugs, Chinese HerbalHumansProto-Oncogene Proteins c-bcl-2Stomach NeoplasmsAntineoplastic Agentsbcl-2-Associated X ProteinDrugs, Chinese HerbalProto-Oncogene Proteins c-bcl-2ApoptosisGastric CancerProliferationSide PopulationSijunzi Decoction

Identifiers

PMID28852730
PMCPMC5566137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.