Evidence map›Paper›PMID 28852579›Full record

ArticleParkinson's disease2017

Predictors of Functional and Quality of Life Outcomes following Deep Brain Stimulation Surgery in Parkinson's Disease Patients: Disease, Patient, and Surgical Factors.

Hesham Abboud, Gencer Genc, Nicolas R Thompson, Srivadee Oravivattanakul, Faisal Alsallom, Dennys Reyes, Kathy Wilson, Russell Cerejo, Xin Xin Yu, Darlene Floden and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinson's disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Article
  6. Review
  7. Wearable haptic anklets for gait and freezing improvement in Parkinson's disease: a proof-of-concept study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  8. Article
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  10. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Hesham AbboudCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.ORCID 0000-0001-5346-8254
Gencer GencCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Nicolas R ThompsonDepartment of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Avenue, Mail Code JJN3-01, Cleveland, OH 44195, USA.
Srivadee OravivattanakulCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Faisal AlsallomCase Western Reserve University, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Dennys ReyesDepartment of Neurology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Fl 3, Weston, FL 33331, USA.
Kathy WilsonCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Russell CerejoCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Xin Xin YuCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Darlene FlodenCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Anwar AhmedCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Michal GostkowskiCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Ayman EzzeldinDepartment of Neurology, Alexandria University, El Hadara University Hospital, El Hadara Kebly, Alexandria, Egypt.
Hazem MaroufDepartment of Neurology, Alexandria University, El Hadara University Hospital, El Hadara Kebly, Alexandria, Egypt.
Ossama Y MansourDepartment of Neurology, Alexandria University, El Hadara University Hospital, El Hadara Kebly, Alexandria, Egypt.ORCID 0000-0001-8814-6431
Andre MachadoCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Hubert H FernandezCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Avenue, Mail Code U2, Cleveland, OH 44195, USA.
Cleveland Clinic · USAlexandria University · EGCleveland Clinic Florida · USUniversity Hospitals of Cleveland · US

Funding

Neurophysiology of response inhibition in PDK23NS091344 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FLODEN, DARLENE · 2015 to 2019
$843k
NINDS NIH HHS K23 NS091344
6 · The paper itself

Abstract

objectiveThe primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson's disease (PD) patients. The secondary objective was to identify predictors of global improvement.

methodsPD patients who underwent DBS at our Center from 2006 to 2011 were evaluated by chart review and email/phone survey. Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score. For global outcomes, we utilized the Patient Global Impression of Change Scale (PGIS) and the Clinician Global Impression of Change Scale (CGIS).

resultsThere were 130 patients in the dataset. Preoperative and postoperative UPDRS II and EQ-5D were available for 45 patients, PGIS for 67 patients, and CGIS for 116 patients. Patients with falls/postural instability had 6-month functional scores and 1-year QOL scores that were significantly worse than patients without falls/postural instability. For every 1-point increase in preoperative UPDRS III and for every 1-unit increase in body mass index (BMI), the 6-month functional scores significantly worsened. Patients with tremors, without dyskinesia, and without gait-freezing were more likely to have "much" or "very much" improved CGIS.

conclusionsPresence of postural instability, high BMI, and worse baseline motor scores were the greatest predictors of poorer functional and QOL outcomes after DBS.

Identifiers

PMID28852579
PMCPMC5568614
OpenAlexW2745310099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.