ArticleClinical kidney journal2017
Gastrointestinal complications induced by sevelamer crystals.
Article in Clinical kidney journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Histopathological lesions of the gastrointestinal tract associated with the use of polystyrene sulfonate and sevelamer: a meta-analysis.Pathologica · 2024Pooled it
- Sevelamer carbonate crystal associated colitis in a hemodialysis patient: a case report.Oxford medical case reports · 2026Article
- Signal detection and analysis of adverse events associated with sevelamer post-marketing based on the FAERS database.Medicine · 2026Article
- Article
- Sevelamer-Associated Colitis as a Colon Cancer Mimicker.Gastro hep advances · 2025Article
- Sevelamer-Induced Ischemic Enteritis.ACG case reports journal · 2024Article
- Association of Sevelamer Initiation with Gastrointestinal Bleeding Hospitalization in Individuals Requiring Hemodialysis.American journal of nephrology · 2024Article
- Sevelamer-induced Gastrointestinal Mucosal Injury: A Critical Review for Clinicians.Journal of community hospital internal medicine perspectives · 2024Review
- Case report: Sevelamer-associated colitis-a cause of pseudotumor formation with colon perforation and life-threatening bleeding.Frontiers in medicine · 2023Article
- Unusual cause of colonic mucosal ulceration and gastrointestinal bleeding.Frontline gastroenterology · 2022Article
- Diagnosis of Ion-Exchange Resin Depositions in Paraffin Sections Using Correlative Light and Electron Microscopy-NanoSuit Method.Diagnostics (Basel, Switzerland) · 2021Article
- [Colonic Mass Secondary to Sevelamer-associated Rectal Ulcer].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021Article
- Sevelamer crystals-an unusual cause of large bowel obstruction.Journal of surgical case reports · 2021Article
- Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Lower gastrointestinal bleeding in a patient receiving sevelamer: Case report.SAGE open medical case reports · 2021Article
- Article
- Phosphate binders in chronic kidney disease: an updated narrative review of recent data.Journal of nephrology · 2020Review
- Observational
- Sevelamer Carbonate Crystal-Induced Colitis.Case reports in gastrointestinal medicine · 2020Article
- Clopidogrel Drug Interactions and Serious Bleeding: Generating Real-World Evidence via Automated High-Throughput Pharmacoepidemiologic Screening.Clinical pharmacology and therapeutics · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevelamer is a phosphate binder widely used in chronic kidney disease (CKD) patients. Sevelamer, as well as other resin-based binders, can crystallize leading to the formation of concretions. Sevelamer crystals (SC) have been associated with gastrointestinal (GI) mucosal injury. We describe three new cases of GI lesions associated with SC and review previously reported cases.
methodsWe describe three new cases of GI lesions associated with SC and review previously reported cases.
resultsWe found 16 previously reported cases of SC-induced GI lesions. The mean patient age was 61 years (interquartile range 51.5-71.75), 62.5% were females and 10 patients were diabetic. In 13 cases, SC was found inside the GI mucosa. Six patients had history of major abdominal surgery. GI bleeding was the most common clinical symptom (
conclusionsSC-induced GI lesions should be considered in CKD patients treated with sevelamer who present GI symptoms, especially lower GI bleeding, once other causes have been ruled out. Diabetics seem more prone to develop SC- associated GI lesions. Sevelamer therapy should be avoided if possible in patients with a history of major abdominal surgery or chronic constipation, because of the high risk of serious GI complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.