ArticleIranian journal of basic medical sciences2017
Staging of colorectal cancer using serum metabolomics with
Article in Iranian journal of basic medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Review
- Serum Colorectal Cancer Biomarkers Unraveled by NMR Metabolomics: Past, Present, and Future.Analytical chemistry · 2022Article
- Non-absorbable antibiotic treatment inhibits colorectal cancer liver metastasis by modulating deoxycholic acid metabolism by intestinal microbes.Journal of Cancer · 2022Article
- Untargeted GC-MS-Based Metabolomics for Early Detection of Colorectal Cancer.Frontiers in oncology · 2021Article
- Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium.International journal of cancer · 2020Article
- Profiling of serum metabolites in advanced colon cancer using liquid chromatography-mass spectrometry.Oncology letters · 2020Article
- Feature of Heart Rate Variability and Metabolic Mechanism in Female College Students with Depression.BioMed research international · 2020Article
- Global serum metabolomics profiling of colorectal cancer.Molecular and clinical oncology · 2019Review
- Metabolomics Profiling on Different Stages of Colorectal Cancer: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2018Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDetermination of stages of colon cancer is done by biopsy usually after surgery. Metabolomics is the study of all the metabolites using LC-MS and MATERIALS AND
methodsFive ml blood was collected from 16 confirmed patients referred for colonoscopy. One group of eight patients were diagnosed with stage 0 to I colon cancer and the second group of 8 patients with II-IV stage colon cancer. Sera were sent for
resultsSix metabolites of which pyridoxine levels lowered, and glycine, cholesterol, taurocholic acid, cholesteryl ester and deoxyinosine increased.
conclusionThe different stages of cancer were identified by the main metabolic cycles such as primary bile acid biosynthesis, purine and vitamin B metabolic pathways and the glutathione cycle.
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